• 2022
• 2021
• 2020
• 2019
• 2018
• 2017
• 2016
• 2015
• 2014
• 2013
• 2012
• 2011
• 2010
• 2009
• 2008
• 2007
• 2006
• 2005
• 2004

2022年

• Tatsuya Ioka,Masashi Kanai,Shogo Kobayashi,Daisuke Sakai,Hidetoshi Eguchi,Hideo Baba,Satoru Seo,Akinobu Taketomi,Tadatoshi Takayama,Hiroki Yamaue,Masahiro Takahashi,Masayuki Sho,Keiko Kamei,Jiro Fujimoto,Masanori Toyoda,Junzo Shimizu,Takuma Goto,Yoshitaro Shindo,Kenichi Yoshimura,Etsuro Hatano,Hiroaki Nagano ,Kansai Hepatobiliary Oncology Group (KHBO)

  Randomized phase III study of Gemcitabine, Cisplatin plus S-1 (GCS) versus Gemcitabine, Cisplatin (GC) for Advanced Biliary Tract Cancer (KHBO1401-MITSUBA).

  J Hepatobiliary Pancreat Sci. (in press)

• Yoshinobu Yamamoto,Naohiro Yoshida,Tomonori Yano,Takahiro Horimatsu,Noriya Uedo ,Noboru Kawata,Hiromitsu Kanzaki,Shinichiro Hori,Kenshi Yao,Seiichiro Abe,Chikatoshi Katada,Chizu Yokoi,Ken Ohata,Hisashi Doyama,Kenichi Yoshimura,Hideki Ishikawa,Manabu Muto.

  Assessment of Outcomes From 1-Year Surveillance After Detection of Early Gastric Cancer Among Patients at High Risk in Japan.

  JAMA Netw Open. 2022 Aug 1;5(8):e2227667.

• Yoshihiro Yamamoto,Keita Fukuyama,Masashi Kanai,Tomohiro Kondo,Masahiro Yoshioka,Tadayuki Kou,Pham Nguyen Quy,Reiko Kimura-Tsuchiya,Takahiro Yamada,Shigemi Matsumoto,Shinji Kosugi,Manabu Muto.

  Prevalence of pathogenic germline variants in the circulating tumor DNA testing.

  Int J Clin Oncol. 2022 Jul 23. (in press)

• Uneno Y, Iwai M, Morikawa N, Tagami K, Matsumoto Y, Nozato J, Kessoku T, Shimoi T, Yoshida M, Miyoshi A, Sugiyama I, Mantani K, Itagaki M, Yamagishi A, Morita T, Inoue A, Muto M.

  Development of a national health policy logic model to accelerate the integration of oncology and palliative care: a nationwide Delphi survey in Japan.

  Int J Clin Oncol. 2022 Jun 17.

• Yosuke Mitani,Shinya Ohashi,Osamu Kikuchi,Yukie Nakai,Tomomi Ida,Ayaka Mizumoto,Yoshihiro Yamamoto,Tomoki Saito,Shigeki Kataoka,Junichi Matsubara,Atsushi Yamada,Masashi Kanai,Shigemi Matsumoto,Hiroaki Sakai,Kiyotsugu Yoshikawa,Eijiro Nakamura,Manabu Muto.

  HER2 G776S Mutation Promotes Oncogenic Potential in Colorectal Cancer Cells when Accompanied by Loss of APC Function.

  Sci Rep. 2022 Jun 2;12(1):9213.

• Akari Minamoto,Takahiro Yamada,Saki Shimada,Ichiro Kinoshita,Yoko Aoki,Katsutoshi Oda,Arisa Ueki,Satomi Higashigawa,Maki Morikawa,Yuki Sato,Akira Hirasawa,Masanobu Ogawa,Tomohiro Kondo,Masahiro Yoshioka,Masashi Kanai,Manabu Muto,Shinji Kosugi.

  Current status and issues related to secondary findings in the first public insurance covered tumor genomic profiling in Japan: multi-site questionnaire survey.

  J Hum Genet. (in press)

• Tomohiro Kondo, Yoshihiro Yamamoto, Keita Fukuyama, Masashi Kanai, Atsushi Yamada, Junichi Matsubara, Pham Nguyen Quy, Masahiro Yoshioka, Takahiro Yamada, Sachiko Minamiguchi, Shigemi Matsumoto, Shinji Kosugi, Manabu Muto.

  Germline sequencing for presumed germline pathogenic variants via tumor-only comprehensive genomic profiling. Int J Clin Oncol. (in press)

• Takahiro Inoue,Ryu Ishihara,Tomotaka Shibata,Kosuke Suzuki,Yuko Kitagawa,Tatsuya Miyazaki,Taiki Yamaji,Kenji Nemoto,Tsuneo Oyama,Manabu Muto,Hiroya Takeuchi,Yasushi Toh,Hisahiro Matsubara,Masayuki Mano,Koji Kono,Ken Kato,Masahiro Yoshida,Hirofumi Kawakubo,Eisuke Booka,Tomoki Yamatsuji,Hiroyuki Kato,Yoshinori Ito,Hitoshi Ishikawa,Takahiro Tsushima,Hiroshi Kawachi,Takashi Oyama,Takashi Kojima,Shiko Kuribayashi,Tomoki Makino,Satoru Matsuda,Yuichiro Doki,Esophageal Cancer Practice Guidelines Preparation Committee.

  Endoscopic imaging modalities for diagnosing the invasion depth of superficial esophageal squamous cell carcinoma: a systematic review.

  Esophagus. 2022 Jul;19(3):375-383.

• Pham Nguyen Quy,Keita Fukuyama,Masashi Kanai,Tadayuki Kou,Tomohiro Kondo,Masahiro Yoshioka,Junichi Matsubara,Tomohiro Sakuma,Sachiko Minamiguchi,Shigemi Matsumoto,Manabu Muto.

  Inter-Assay Variability of Next-Generation Sequencing-Based Gene Panels.
  BMC Med Genomics. 2022 Apr 15;15(1):86.

• Kuno Suzuki, Hideyoshi Igata, Motoki Abe, Yusuke Yamamoto, small RNA based cancer classification project.

  Multiple cancer type classification by small RNA expression profiles with plasma samples from multiple facilities.

  Cancer Sci. 2022 Feb 26.

• Manabu Muto,Chikatoshi Katada,Tetsuji Yokoyama,Tomonori Yano,Ichiro Oda,Yasumasa Ezoe,Satoshi Tanabe,Yuichi Shimizu,Hisashi Doyama,Tomoyuki Koike,Kohei Takizawa,Motohiro Hirao,Hiroyuki Okada,Takashi Ogata,Atsushi Katagiri,Takenori Yamanouchi,Yasumasa Matsuo,Hirofumi Kawakubo,Tai Omori,Nozomu Kobayashi,Tadakazu Shimoda,Atsushi Ochiai,Hideki Ishikawa,Kiichiro Baba,Yusuke Amanuna,Akira Yokoyama,Shinya Ohashi,Akira Yokoyama,forJapan Esophageal Cohort Study Group.

  Field Effect of Alcohol, Cigarette Smoking, and Their Cessation on the Development of Multiple Dysplastic Lesions and Squamous Cell Carcinoma: A Long-term Multicenter Cohort Study.

  Gastro Hep Advances.VOLUME 1, ISSUE 2, P265-276, JANUARY 01, 2022

• Yukiko Mori, Osamu Kikuchi, Takahiro Horimatsu, Hiroki Hara, Shuichi Hironaka, Takashi Kojima, Ken Kato, Takahiro Tsushima, Ryu Ishihara, Kumi Mukai, Ryuji Uozumi, Harue Tada, Hiroi Kasai, Atsushi Kawaguchi, Manabu Muto.

  Multicenter phase II study of trifluridine/tipiracil for esophageal squamous carcinoma refractory/intolerant to 5-fluorouracil, platinum compounds, and taxanes: the ECTAS study.

  Esophagus. 2022 Jul;19(3):444-451.

• Taro Oshikiri,Hodaka Numasaki,Junya Oguma,Yasushi Toh,Masayuki Watanabe,Manabu Muto,Yoshihiro Kakeji,Yuichiro Doki.

  Prognosis of Patients with Esophageal Carcinoma following Routine Thoracic Duct Resection: A Propensity-matched Analysis of 12,237 Patients based on the Comprehensive Registry of Esophageal Cancer in Japan.

  Ann Surg. (in press)

2021年

• Atsushi Yamada, Yui Matsuoka, Sachiko Minamiguchi, Yoshihiro Yamamoto, Tomohiro Kondo, Tomohiko Sunami, Takahiro Horimatsu, Kenji Kawada, Hiroshi Seno, Masako Torishima, Hiromi Murakami, Takahiro Yamada, Shinji Kosugi, Kokichi Sugano, Manabu Muto.

  Real-world outcome of universal screening for Lynch syndrome in Japanese patients with colorectal cancer highlights the importance of targeting patients with young-onset disease.

  Mol Clin Oncol. 2021 Dec;15(6):247.

• M Kanai, T Kawaguchi, M Kotaka, D Manaka, J Hasegawa, A Takagane, Y Munemoto, T Kato, T Eto, T Touyama, T Matsui, K Shinozaki, S Matsumoto, T Mizushima, M Mori, J Sakamoto, A Ohtsu, T Yoshino, S Saji, F Matsuda.

  Large-scale prospective genome-wide association study of oxaliplatin in stage II/III colon cancer and neuropathy.

  Ann Oncol. 2021 Nov;32(11):1434-1441.

• Matsuoka Y, Iemura Y, Fujimoto M, Shibuya S, Yamada A, Fujii S, Kusaka T, Shindo T, Minamiguchi S, Haga H.

  Upper Gastrointestinal Langerhans Cell Histiocytosis: A Report of 2 Adult Cases and a Literature Review.

  Int J Surg Pathol. 2021 Aug;29(5):550-556.

• Shuko Morita,Kenichi Goda,Tomonori Yano,Mitsuru Kaise,Mototsugu Kato,Haruhiro Inoue,Yasumasa Niwa,Shinya Kodashima,Ryoji Miyahara,Atsushi Ochiai,Masahiro Ikegami, Shigeharu Hamatani,Tadakazu Shimoda,Yasuo Ohkura,Junko Aida,Yukihiro Nakanishi, Kenichi Yoshimura,Hideki Ishikawa,Kaiyo Takubo,Manabu Muto.

  Multicenter prospective in vivo study of an endocytoscope system (ECS) for superficial esophageal cancer.

  J Gastroenterol. 2021 Sep;56(9):808-813.

• Satoko Ito, Tatsuya Morita, Yu Uneno, Tomohiko Taniyama, Yosuke Matsuda, Hiroyuki Kohara, Isseki Maeda, Takeo Nakayama, Masanori Mori, EASED Investigators
  Incidence and associated factors of sudden unexpected death in advanced cancer patients: A multicenter prospective cohort study.  

  Cancer Med. 2021 Jul;10(14):4939-4947.

• Shinya Ohashi, Takahisa Maruno, Keita Fukuyama, Osamu Kikuchi, Tomohiko Sunami, Yuki Kondo, Seiichiro Imai, Aki Matsushima, Kazuyo Suzuki, Fumika Usui, Masahiro Yakami, Atsushi Yamada, Hiroyoshi Isoda, Shigemi Matsumoto, Hiroshi Seno, Manabu Muto, Mayumi Inoue.

  Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40-69-years subjects.

  Esophagus. 2021 Oct;18(4):889-899.

• Masashi Tamaoki, Akira Yokoyama,Takahiro Horimatsu, Kenshiro Hirohashi, Yusuke Amanuma, Hirokazu Higuchi, Yosuke Mitani, Masahiro Yoshioka, Shinya Ohashi, Manabu Muto.

  Repeated talaporfin sodium photodynamic therapy for esophageal cancer: safety and efficacy

  Esophagus. 2021 Oct;18(4):817-824.

• Chikatoshi Katada, Manabu Muto, Satoshi Fujii, Tetsuji Yokoyama, Tomonori Yano, Akihito Watanabe, Toshiro Iizuka, Shigetaka Yoshinaga, Ichiro Tateya, Hiroki Mitani, Yuichi Shimizu, Akiko Takahashi, Tomoyuki Kamijo, Noboru Hanaoka, Makoto Abe, Akihiro Shiotani, Koichi Kano, Yukinori Asada, Tamotsu Matsuhashi, Hirohito Umeno, Kenji Okami, Kenichi Goda, Shinichiro Hori, Yoichiro Ono, Shuji Terai, Yasuaki Nagami, Kenichi Takemura, Kenro Kawada, Mizuo Ando, Naoto Shimeno, Akihito Arai, Yasutoshi Sakamoto, Masaaki Ichinoe, Tetsuo Nemoto, Masahiro Fujita, Hidenobu Watanabe, Tadakazu Shimoda, Atsushi Ochiai, Takakuni Kato, Ryuichi Hayashi.

  Transoral surgery for superficial head and neck cancer: National Multi-Center Survey in Japan.

  Cancer Med. 2021 Jun;10(12):3848-3861.

• Koyanagi M, Imai S, Matsumoto M, Iguma Y, Kawaguchi-Sakita N, Kotake T, Iwamitsu Y, Ntogwa M, Hiraiwa R, Nagayasu K, Saigo M, Ogihara T, Yonezawa A, Omura T, Nakagawa S, Nakagawa T, Matsubara K.

  Pro-nociceptive roles of Schwann cell-derived galectin-3 in taxane-induced peripheral neuropathy.

  Cancer Res. 2021 Apr 15;81(8):2207-2219.

• Yamada A, Nishio M,Maruno T, Funakoshi M, and Furukawa M.

  Safety of esophagogastroduodenoscopy in individuals harboring unruptured intracranial aneurysms.

  Eur J Gastroenterol Hepatol. 2021 May 1;33(5):765-766.

• Maruki Y, Morizane C, Arai Y, Ikeda M, Ueno M, Ioka T, Naganuma A, Furukawa M, Mizuno N, Uwagawa T, Takahara N, Kanai M, Asagi A, Shimizu S, Miyamoto A, Yukisawa S, Kadokura M, Kojima Y, Furuse J, Nakajima TE, Sudo K, Kobayashi N, Hama N, Yamanaka T, Shibata T, Okusaka T.

  Molecular detection and clinicopathological characteristics of advanced/recurrent biliary tract carcinomas harboring the FGFR2 rearrangements: a prospective observational study (PRELUDE Study).

  J Gastroenterol. 2021 Mar;56(3):250-260.

• Sunami K, Naito Y, Aimono E, Amano T, Ennishi D, Kage H, Kanai M, Komine K, Koyama T, Maeda T, Morita S, Sakai D, Kohsaka S, Tsuchihara K, Yoshino T.

  The initial assessment of expert panel performance in core hospitals for cancer genomic medicine in Japan.

  Int J Clin Oncol. 2021 Mar;26(3):443-449.

• Yusuke Amanuma, Takahiro Horimatsu, Shinya Ohashi, Masashi Tamaoki, Manabu Muto.
  Association of local complete response with prognosis after salvage photodynamic therapy for esophageal squamous cell carcinoma.
  Dig Endosc. 2021 Mar;33(3):355-363.

• Kohei Takizawa, Hiroyuki Ono, Noriaki Hasuike, Atsuo Takashima, Keiko Minashi, Narikazu Boku, Ryoji Kushima, Hiroshi Katayama, Gakuto Ogawa, Haruhiko Fukuda, Junko Fujisaki, Ichiro Oda, Tomonori Yano, Shinichiro Hori, Hisashi Doyama, Kingo Hirasawa, Yoshinobu Yamamoto, Ryu Ishihara, Satoshi Tanabe, Yasumasa Niwa, Masahiro Nakagawa, Masanori Terashima, Manabu Muto the Gastrointestinal Endoscopy Group (GIESG) and the Stomach Cancer Study Group (SCSG) of Japan Clinical Oncology Group

  A nonrandomized, single-arm confirmatory trial of expanded endoscopic submucosal dissection indication for undifferentiated early gastric cancer: Japan Clinical Oncology Group study (JCOG1009/1010)

  Gastric Cancer. 2021 Mar;24(2):479-491.

• Masashi Takeuchi, Chiyo K Imamura, Eisuke Booka, Hiroya Takeuchi, Takuro Mizukami, Takeshi Kawakami, Taro Funakoshi, Kazushige Wakuda, Yu Aoki, Yasuo Hamamoto, Minoru Kitago, Hirofumi Kawakubo, Narikazu Boku, Yusuke Tanigawara, Yuko Kitagawa.

  Prospective evaluation and refinement of an S-1 dosage formula based on renal function for clinical application.

  Cancer Sci. 2021 Feb;112(2):751-759.

• Naito Y, Aburatani H, Amano T, Baba E, Furukawa T, Hayashida T, Hiyama E, Ikeda S, Kanai M, Kato M, Kinoshita I, Kiyota N, Kohno T, Kohsaka S, Komine K, Matsumura I, Miura Y, Nakamura Y, Natsume A, Nishio K, Oda K, Oda N, Okita N, Oseto K, Sunami K, Takahashi H, Takeda M, Tashiro S, Toyooka S, Ueno H, Yachida S, Yoshino T, Tsuchihara K; Japanese Society of Medical Oncology; Japan Society of Clinical Oncology; Japanese Cancer Association.

  Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1).

  Int J Clin Oncol. 2021 Feb;26(2):233-283.

• Naohiro Yoshida, Hisashi Doyama, Tomonori Yano, Takahiro Horimatsu, Noriya Uedo, Yoshinobu Yamamoto, Naomi Kakushima, Hiromitsu Kanzaki, Shinichiro Hori, Kenshi Yao, Ichiro Oda, Chikatoshi Katada, Chizu Yokoi, Ken Ohata, Kenichi Yoshimura, Hideki Ishikawa, Manabu Muto.
  Early gastric cancer detection in high-risk patients: a multicentre randomised controlled trial on the effect of second-generation narrow band imaging.
  Gut. 2021 Jan;70(1):67-75.

2020年

• M Kawashima, M Murakami, T Saito, I Oyama, M Tauchi, K Oikawa, M Sekine, T Sekine, N Ozawa, Y.Saito, H Yamaji, Y Yagiuchi, A Kumagai and K Otani.

  Lessons from and perspectives for healthcare student volunteer activities after the Fukushima disaster.

  Radioprotection 2020, 55(4), 271–276.

• Mitani Y, Kanai M, Kou T, Kataoka S, Doi K, Matsubara J, Ohashi S, Matsumoto S, Muto M.

  Cancer of unknown primary with EGFR mutation successfully treated with targeted therapy directed by clinical next-generation sequencing: a case report.

  BMC Cancer. 2020 Dec 2;20(1):1177.

• Iwai T, Yoshimura M, Ashida R, Goto Y, Kishi T, Itasaka S, Shibuya K, Kanai M, Masui T, Fukuda A, Isoda H, Hiraoka M, Mizowaki T.

  Hypofractionated intensity-modulated radiotherapy with concurrent chemotherapy for elderly patients with locally advanced pancreatic carcinoma.

  Radiat Oncol. 2020 Nov 13;15(1):264.

• Naomi Kakushima, Naohiro Yoshida, Hisashi Doyama, Tomonori Yano, Takahiro Horimatsu, Noriya Uedo, Yoshinobu Yamamoto, Hiromitsu Kanzaki, Shinichiro Hori, Kenshi Yao, Ichiro Oda, Satoshi Tanabe, Chizu Yokoi, Ken Ohata, Kenichi Yoshimura, Hideki Ishikawa & Manabu Muto.

  Near-focus magnification and second-generation narrow-band imaging for early gastric cancer in a randomized trial

  J Gastroenterol. 2020 Dec;55(12):1127-1137.

• Okano N, Morizane C, Nomura S, Takahashi H, Tsumura H, Satake H, Mizuno N, Tsuji K, Shioji K, Asagi A, Yasui K, Kitagawa S, Kashiwada T, Ishiguro A, Kanai M, Ueno M, Ogura T, Shimizu S, Tobimatsu K, Motoya M, Nakashima K, Ikeda M, Okusaka T, Furuse J.

  Phase II clinical trial of gemcitabine plus oxaliplatin in patients with metastatic pancreatic adenocarcinoma with a family history of pancreatic/breast/ovarian/prostate cancer or personal history of breast/ovarian/prostate cancer (FABRIC study).

  Int J Clin Oncol. 2020 Oct;25(10):1835-1843.

• Inagaki-Kawata Y, Yoshida K, Kawaguchi-Sakita N, Kawashima M, Nishimura T, Senda N, Shiozawa Y, Takeuchi Y, Inoue Y, Sato-Otsubo A, Fujii Y, Nannya Y, Suzuki E, Takada M, Tanaka H, Shiraishi Y, Chiba K, Kataoka Y, Torii M, Yoshibayashi H, Yamagami K, Okamura R, Moriguchi Y, Kato H, Tsuyuki S, Yamauchi A, Suwa H, Inamoto T, Miyano S, Ogawa S, Toi M.

  Genetic and clinical landscape of breast cancers with germline BRCA1/2 variants.

  Commun Biol. 2020 Oct 16;3(1):578.

• Tomohiro Kondo, Junichi Matsubara, Pham Nguyen Quy, Keita Fukuyama, Motoo Nomura,Taro Funakoshi, Keitaro Doi, Yuichi Sakamori, Masahiro Yoshioka, Akira Yokoyama, Masashi Tamaoki, Tadayuki Kou, Kenshiro Hirohashi, Atsushi Yamada, Yoshihiro Yamamoto, Sachiko Minamiguchi, Masakazu Nishigaki, Takahiro Yamada, Masashi Kanai, Shigemi Matsumoto, Manabu Muto.

  Comprehensive genomic profiling for patients with chemotherapy-naïve advanced cancer.

  Cancer Sci. 2020 Oct 2;112(1):296-304.

• Yoshinao Ozaki, Hirotaka Imamaki, Aki Ikeda, Mitsuaki Oura, Shunsaku Nakagawa, Taro Funakoshi, Shigeki Kataoka, Yoshitaka Nishikawa, Takahiro Horimatsu, Atsushi Yonezawa, Takeshi Matsubara, Motoko Yanagita, Manabu Muto, Norihiko Watanabe.

  Successful management of hyperammonemia with hemodialysis on day 2 during 5-fluorouracil treatment in a patient with gastric cancer: a case report with 5-fluorouracil metabolite analyses

  Cancer Chemother Pharmacol.2020 Nov;86(5):693-699.

• Prasannna M Chandranouleeswaran, Manti Guha, Masataka Shimonosono, Kelly A. Whealan, Gordon Ruthel, Sarmistha Mukherjee, Michael V Gonzalez, James Garifallou, Clementina Amesaros, Ian A. Blair, Renata Pellegrino, Eishi Noguchi, Hakon Hakonarson, Joseph A. Baur, Noah Engel, Hisatsugu Maekawa, Uma M. Sachdeva, Shinya Ohashi, Andres Klein-Szanto, Hiroshi Nakagawa.

  Autophagy migrates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes.

  PLoS One. 2020 Sep 23;15(9):e0239625.

• Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Ichiro Oda, Yuichi Shimizu, Kenichi Takemura, Tomoyuki Koike, Kohei Takizawa, Motohiro Hirao, Hiroyuki Okada, Norisuke Nakayama, Yutaro Kubota, Yasumasa Matsuo, Hirofumi Kawakubo, Hideki Ishikawa, Akira Yokoyama, Manabu Muto.

  Association between the findings of metachronous secondary primary malignancies and the number of Lugol-voiding lesions.

  Dis Esophagus. 2020 Sep 4;33(9):doz110.

• Shigeyuki Matsumoto, Mitsugu Araki, Yuta Isaka, Fumie Ono, Kenshiro Hirohashi, Shinya Ohashi, Manabu Muto, Yasushi Okuno.

  E487K-induced disorder in functionally relevant dynamics of mitochondrial aldehyde dehyderogenase 2.

  Biophys J. 2020 Aug 4;119(3):628-637.

• Akira Yokoyama, Chikatoshi Katada, Tetsuji Yokoyama, Kohei Takizawa, Tomonori Yano, Ichiro Oda, Yuichi Shimizu , Hiroyoshi Nakanishi, Tomoyuki Koike, Motohiro Hirao, Hiroyuki Okada, Takako Yoshii, Atsushi Katagiri, Takenori Yamanouchi, Yasumasa Matsuo, Hirofumi Kawakubo, Nozomu Kobayashi, Hideki Ishikawa, Manabu Muto.
  The Alcohol Use Disorders Identification Test and the risk of metachronous cancer after endoscopic resection of esophageal cancer.
  Carcinogenesis. 2020 Aug 12;41(8):1049-1056.

• Tomohiro Kondo, Masashi Kanai, Junichi Matsubara, Pham Nguyen Quy, Keita Fukuyama, Yoshihiro Yamamoto, Takahiro Yamada, Masakazu Nishigaki, Sachiko Minamiguchi, Masayuki Takeda, Kazuto Nishio, Shigemi Matsumoto, Manabu Muto.
  BRCA2 Reversion Mutation Identified by Liquid Biopsy After Durable Response to FOLFIRINOX in BRCA2-Associated Pancreatic Cancer.
  Pancreas. Nov/Dec 2020;49(10):e101-e103.

• Kenta Takahashi, Eri Ishibashi, Toshio Kubo, Yohei Harada, Hideyuki Hayashi, Masayuki Kano, Yasushi Shimizu, Hidekazu Shirota, Yukiko Mori, Manabu Muto, Chikashi Ishioka, Hirotoshi Dosaka-Akita, Hisahiro Matsubara, Hiroshi Nishihara, Naoko Sueoka-Aragane, Shinichi Toyooka, Akihiro Hirakawa, Ukihide Tateishi, Satoshi Miyake, Sadakatsu Ikeda.
  A phase 2 basket trial of combination therapy with trastuzumab and pertuzumab in patients with solid cancers harboring human epidermal growth factor receptor 2 amplification (JUPITER trial)
  Medicine (Baltimore). 2020 Aug 7;99(32):e21457.

• Nguyen Hai Nam, Kojiro Taura, Masashi Kanai, Keita Fukuyama, Norimitsu Uza, Hirona Maeda, Yojiro Yutaka,Toyofumi F Chen-Yoshikawa, Manabu Muto, Shinji Uemoto.
  Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs: A case report
  World J Gastroenterol . 2020 Jan 21;26(3):366-374.

• Tomohiro Kadota, Hiroaki Ikematsu, Takeshi Sasaki, Yutaka Saito, Masaaki Ito, Tomonori Mizutani, Gakuto Ogawa, Kohei Shitara, Yoshinori Ito, Ryoji Kushima, Yukihide Kanemitsu ,Manabu Muto.

  Protocol for a single-arm confirmatory trial of adjuvant chemoradiation for patients with high-risk rectal submucosal invasive cancer after local resection: Japan Clinical Oncology Group Study JCOG1612 (RESCUE study)

  BMJ Open. 2020 Jul 14;10(7):e034947.

• Ichiro Oda, Yuichi Shimizu, Toshiyuki Yoshio, Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Haruhisa Suzuki, Satoshi Abiko, Kenichi Takemura, Tomoyuki Koike, Kohei Takizawa, Motohiro Hirao, Hiroyuki Okada, Takako Yoshii, Atsushi Katagiri, Takenori Yamanouchi, Yasumasa Matsuo, Hirofumi Kawakubo, Nozomu Kobayashi, Tadakazu Shimoda, Atsushi Ochiai, Hideki Ishikawa, Akira Yokoyama, Manabu Muto.
  Long-term outcome of endoscopic resection for intramucosal esophageal squamous cell cancer: a secondary analysis of the Japan Esophageal Cohort study.
  Endoscopy.2020 Nov;52(11):967-975.

• Shigeki Kataoka, Yoshitaka Nishikawa, Taro Funakoshi, Takahiro Horimatsu, Naoya Kondo, Takeshi Matsubara, Motoko Yanagita, Shigemi Matsumoto, Manabu Muto.
  Long-term survival and renal dysfunction in a patient with recurrent colorectal cancer treated with Bevacizumab: a case report.
  Clin J Gastroenterol.2020 Jun;13(3):316-319.

• Agatsuma N, Nishikawa Y, Horimatsu T, Nakatani Y, Juri N, Akamatsu T, Seta T, Minamiguchi S, Yamashita Y.

  Bone metastasis as a recurrence of early papillary adenocarcinoma of the stomach.

  Clin J Gastroenterol. 2020 Jun;13(3):349-353.

• Truong-Minh Pham, Pham Nguyen Quy, Takahiro Horimatsu, Manabu Muto, Lorraine Shack, Winson Y. Cheung, Tatsuhiko Kubo, Yoshihisa Fujino, Shinya Matsuda.
  Premature mortality due to stomach cancer in Japan: a nationwide analysis from 1980 to 2015.
  Annals of Epidemiology. Volume 47, July 2020, Pages 19-24

• Takeshi Shinozaki, Chikatoshi Katada, Kiyoto Shiga, Takahiro Asakage, Tetsuji Yokoyama, Tomonori Yano, Ichiro Oda, Yuichi Shimizu, Kenichi Takemura, Hideki Ishikawa, Akira Yokoyama, Manabu Muto.
  Effectiveness of Planned Surveillance for Detecting Second Primary Head and Neck Cancers After Endoscopic Resection of Esophageal Squamous Cell Carcinoma.
  Jpn J Clin Oncol.2020 Sep 28;50(10):1162-1167.

• Uneno Y, Imura H, Makuuchi Y, Tochitani K, Watanabe N.
  Pre-emptive antifungal therapy versus empirical antifungal therapy for febrile neutropenia in people with cancer (Protocol).
  Cochrane Database of Systematic Reviews 2020, Issue 5. Art. No.: CD013604.

• Nomura M, Nagatomo R, Doi K, Shimizu J, Baba K, Saito T, Matsumoto S, Inoue K, Muto M.
  Association of Short-Chain Fatty Acids in the Gut Microbiome With Clinical Response to Treatment With Nivolumab or Pembrolizumab in Patients With Solid Cancer Tumors.
  JAMA Netw Open. 2020 Apr 1;3(4):e202895.

• Ishihara R, Arima M, Iizuka T, Oyama T, Katada C, Kato M, Goda K, Goto O, Tanaka K, Yano T, Yoshinaga S, Muto M, Kawakubo H, Fujishiro M, Yoshida M, Fujimoto K, Tajiri H, Inoue H ; Japan Gastroenterological Endoscopy Society Guidelines Committee of ESD/EMR for Esophageal Cancer.
  Endoscopic submucosal dissection/endoscopic mucosal resection guidelines for esophageal cancer.
  Dig Endosc. 2020 May;32(4):452-493.

• Kato M, Tanaka K, Kida M, Ryozawa S, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H.
  Multicenter database registry for endoscopic retrograde cholangiopancreatography: Japan Endoscopic Database Project.
  Dig Endosc. 2020 May;32(4):494-502.

• Umeta Hitomi, Kishimoto Atsuhiro, Imaizumi Atsushi, Hashimoto Tadashi, Asakura Tadashi, Kakeya Hideaki, Kanai Masashi.
  Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo.
  Cancer Sci . 2020 May;111(5):1785-1793.

• Yoshitaka Nishikawa, Nobuaki Hoshino, Takahiro Horimatsu, Taro Funakoshi, Koya Hida, Yoshiharu Sakai, Manabu Muto, and Takeo Nakayama.
  Chemotherapy for patients with unresectable or metastatic small bowel adenocarcinoma: a systematic review.

  Int J Clin Oncol. 2020 Aug;25(8):1441-1449.

• Hirohashi K, Ohashi S, Amanuma Y, Nakai Y, Ida T, Baba K, Mitani Y, Mizumoto A, Yamamoto Y, Kikuchi O, Matsubara J, Yamada A, Miyamoto S, Seno H, Matsuda T, Muto M.
  Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice.
  Carcinogenesis. 2020 Apr 22;41(2):194-202.

• Katada C, Yokoyama T, Yano T, Oda I, Shimizu Y, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Yoshii T, Kubota Y, Yamanouchi T, Tsuda T, Omori T, Kobayashi N, Suzuki H, Tanabe S, Hori K, Nakayama N, Kawakubo H, Kakushima N, Matsuo Y, Ishikawa H, Yokoyama A, Muto M.
  Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma.
  Esophagus. 2020 Apr;17(2):149-158.

• Yoshitaka Nishikawa, Takahiro Horimatsu, Daisuke Nishizaki, Ayako Kohno, Akira Yokoyama, Masahiro Yoshioka, Koya Hida, Katsuyuki Sakanaka, Sachiko Minamiguchi, Hiroshi Seno, Yoshiharu Sakai, and Takeo Nakayama.
  Qualitative and quantitative analysis of posttreatment strategy after endoscopic resection for patients with T1 colorectal cancer at high risk of lymph-node metastasis.
  J Gastrointest Cancer. 2020 Mar;51(1):242-249.

• Takashima K, Fujii S, Komatsuzaki R, Komatsu M, Takahashi M, Kojima T, Daiko H, Minashi K, Chiwaki F, Muto M, Sasaki H, Yano T.
  CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer.
  Int J Oncol. 2020 Mar;56(3):835-847.

• Shinya Ohashi, Osamu Kikuchi, Yukie Nakai, Tomomi Ida, Tomoki Saito, yuki Kondo, Yoshihiro Yamamoto, Yosuke Mitani, Trang H. Nguyen Vu, Keita Fukuyama, Hiroshi Tsukihara, Norihiko Suzuki, Manabu Muto.
  Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma.
  Mol Cancer Ther. 2020 Jun;19(6):1363-1372.

• Sethi NS, Kikuchi O, Duronio GN, Stachler MD, McFarland JM, Ferrer-Luna R, Zhang Y, Bao C, Bronson R, Patil D, Sanchez-Vega F, Liu JB, Sicinska E, Lazaro JB, Ligon KL, Beroukhim R, Bass AJ.
  Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.

  Nat Genet. 2020 Feb;52(2):219-230.

• Kiichiro Baba, Motoo Nomura, Shinya Ohashi, Takuya Hiratsuka, Yukie Nakai, Tomoki Saito, Yuki Kondo, Keita Fukuyama, Osamu Kikuchi, Atsushi Yamada, Junichi Matsubara, Kenshiro Hirohashi, Yosuke Mitani, Ayaka Mizumoto, Manabu Muto.
  Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect.
  Am J Cancer Res 2020 Feb 1;10(2):440-453.

• Nomura M, Oze I, Masuishi T, Yokota T, Satake H, Iwasawa S, Kato K, Andoh M.
  Multicenter prospective phase II trial of nivolumab in patients with unresectable or metastatic mucosal melanoma.
  Int J Clin Oncol. 2020 May;25(5):972-977.

• Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S, Matsuura M, Horimatsu T, Hirano T, Goto N, Takeuchi Y, Ochi Y, Shiozawa Y, Kogure Y, Watatani Y, Fujii Y, Kim SK, Kon A, Kataoka K, Yoshizato T, Nakagawa MM, Yoda A, Nanya Y, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Sugihara E, Sato TA, Maruyama T, Miyoshi H, Taketo MM, Oishi J, Inagaki R, Ueda Y, Okamoto S, Okajima H, Sakai Y, Sakurai T, Haga H, Hirota S, Ikeuchi H, Nakase H, Marusawa H, Chiba T, Takeuchi O, Miyano S, Seno H, Ogawa S.

  Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.

  Nature. 2020 Jan;577(7789):260-265.

• Uneno Y, Sato K, Morita T, Nishimura M, Ito S, Mori M, Shimizu C, Horie Y, Hirakawa M, Nakajima TE, Tsuneto S, Muto M.
  Current status of integrating oncology and palliative care in Japan: a nationwide survey.
  BMC Palliat Care. 2020 Jan 24;19(1):12.

• Tomohiro Kondo, Shigemi Matsumoto, Keitaro Doi, Motoo Nomura, Manabu Muto.
  Femoral placement of a totally implantable venous access port with spontaneous catheter fracture: Case report.
  CVIR Endovasc. 2020 Jan 6;3(1):2.

• Yoshihiro Yamamoto, Masashi Kanai, Tadayuki Kou, Aiko Sugiyama, Eijiro Nakamura, Hidehiko Miyake, Takahiro Yamada, Masakazu Nishigaki, Tomohiro Kondo, Hiromi Murakami, Masako Torishima, Shigemi Matsumoto, Shinji Kosugi, and Manabu Muto.
  Clinical significance of TP53 variants as possible secondary findings in tumor-only next-generation sequencing.
  J Hum Genet. 2020 Jan;65(2):125-132.

2019年

• Nagaraja AK, Kikuchi O, Bass AJ.
  Genomics and Targeted Therapies in Gastroesophageal Adenocarcinoma.
  Cancer Discov. 2019 Dec;9(12):1656-1672.

• Saito T, Ohashi S, Mizumoto A, Muto M.
  Patient-derived tumor models of esophageal cancer.
  Enzymes. 2019;46:97-111.

• Mori M, Fujimori M, Ishiki H, Nishi T, Hamano J, Otani H, Uneno Y, Oba A, Morita T, Uchitomi Y.
  Adding a Wider Range and “Hope for the Best, and Prepare for the Worst” Statement: Preferences of Patients with Cancer for Prognostic Communication.
  Oncologist. 2019 Sep;24(9):e943-e952.

• Nilay Sethi, Osamu Kikuchi, James McFarland, Yanxi Zhang, Max Chung, Nicholas Kafker, Mirazul Islam, Benjamin Lampson, Abhishek Chakraborty, William G Kaelin Jr, Adam J Bass.

  Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma.

  JCI Insight. 2019 Aug 8;4(15):e128439.

• Keiko Minashi, Keiji Nihei, Junki Mizusawa, Kohei Takizawa, Tomonori Yano, Yasumasa Ezoe, Tomohiro Tsuchida, Hiroyuki Ono, Toshiro Iizuka, Noboru Hanaoka, Ichiro Oda, Yoshinori Morita, Masahiro Tajika, Junko Fujiwara, Yoshinobu Yamamoto, Chikatoshi Katada, Shinichiro Hori, Hisashi Doyama, Tsuneo Oyama, Hiroko Nebiki, Kenji Amagai, Yutaro Kubota, Ken Nishimura, Nozomu Kobayashi, Takuto Suzuki, Kingo Hirasawa, Toshihisa Takeuchi, Haruhiko Fukuda, Manabu Muto.
  Efficacy of Endoscopic Resection and Selective Chemoradiotherapy for Stage I Esophageal Squamous Cell Carcinoma.
  Gastroenterology. 2019 Aug;157(2):382-390.e3.

• Kim SK, Takeda H, Takai A, Matsumoto T, Kakiuchi N, Yokoyama A, Yoshida K, Kaido T, Uemoto S, Minamiguchi S, Haga H, Shiraishi Y, Miyano S, Seno H, Ogawa S, Marusawa H.

  Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.

  J Gastroenterol. 2019 Jul;54(7):628-640.

• Funakoshi T, Miyamoto S, Kakiuchi N, Nikaido M, Setoyama T, Yokoyama A, Horimatsu T, Yamada A, Torishima M, Kosugi S, Yamada H, Sugimura H, Haga H, Sakai Y, Ogawa S, Seno H, Muto M, Chiba T.

  Genetic analysis of a case of Helicobacter pylori-uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer.

  Gastric Cancer. 2019 Jul;22(4):892-898.

• Komatsu-Fujii T, Nomura M, Otsuka A, Ishida Y, Doi K, Matsumoto S, Muto M, Kabashima K.
  Response to imatinib in vaginal melanoma with KIT p.Val559Gly mutation previously treated with nivolumab, pembrolizumab and ipilimumab.
  J Dermatol. 2019 Jun;46(6):e203-e204.

• Mori M, Fujimori M, Ishiki H, Nishi T, Hamano J, Otani H, Uneno Y, Oba A, Morita T, Uchitomi Y.
  The Effects of Adding Reassurance Statements: Cancer Patients’ Preferences for Phrases in End-of-Life Discussions.
  J Pain Symptom Manage. 2019 Jun;57(6):1121-1129.

• Utsumi T, Yamada A, Sakurai T, Miyamoto S.

  Rectal Submucosal Tumor Mimicking a Neuroendocrine Tumor.

  Intern Med. 2019 May 15;58(10):1521-1522.

• Quy Pham Nguyen, Masashi Kanai, Tadayuki Kou, Tomohiro Kondo, Yoshihiro Yamamoto, Junichi Matsubara, Akinori Hiroshima, Hiroaki Mochizuki, Tomohiro Sakuma, Mayumi Kamada, Masahiko Nakatsui, Yuji Eso, Hiroshi Seno, Keita Fukuyama, Toshihiko Masui, Kyoichi Takaori, Sachiko Minamiguchi, Shigemi Matsumoto, Manabu Muto.
  Association between preanalytical factors and tumor mutational burden estimated by next-generation sequencing-based multiplex gene panel assay.
  The Oncologist. 2019 Dec;24(12):e1401-e1408.

• Eso Y, Kou T, Nagai H, Kim YH, Kanai M, Matsumoto S, Mishima-Iwai M, Arasawa S, Iguchi E, Nakamura F, Takeda H, Takai A, Takahashi K, Ueda Y, Muto M, Seno H.

  Utility of ultrasound-guided liver tumor biopsy for next generation sequencing-based clinical sequencing.

  Hepatol Res. 2019 May;49(5):579-589.

• Yamauchi I, Yasoda A, Matsumoto S, Sakamori Y, Kim YH, Nomura M, Otsuka A, Yamasaki T, Saito R, Kitamura M, Kitawaki T, Hishizawa M, Kawaguchi-Sakita N, Fujii T, Taura D, Sone M, Inagaki N.

  Incidence, features, and prognosis of immune-related adverse events involving the thyroid gland induced by nivolumab.

  PLoS One. 2019 May 14;14(5):e0216954.

• Katsuyuki Sakanaka,Kota Fujii,Yuichi Ishida,Shin’ichi Miyamoto,Takahiro Horimatsu,Manabu Muto,Takashi Mizowaki.
  Nutritional and clinical outcomes of chemoradiotherapy for clinical T1N0M0 esophageal carcinoma.
  Cancer Manag Res. 2019 Apr 26;11:3623-3630.

• N.S.S. Atkinson, S. Ket, P. Bassett, D. Aponte, S. De Aguiar, N. Gupta, T. Horimatsu, H. Ikematsu, T. Inoue, T. Kaltenbach, W.K. Leung, T. Matsuda, S. Paggi, F. Radaelli, A. Rastogi, D.K. Rex, L.C. Sabbagh, Y. Saito, Y. Sano, G.M. Saracco, B.P. Saunders, C. Senore, R. Soetiko, K.C. Vemulapalli, V. Jairath, J.E. East.
  Narrow-band Imaging for Detection of Neoplasia at Colonoscopy: a Meta-analysis of Data From Individual Patients in Randomized Controlled Trials.
  Gastroenterology. 2019 Aug;157(2):462-471.

• Yoshitaka Nishikawa, Ayako Kohno, Yoshimitsu Takahashi, Chiaki Suzuki, Hirokatsu Kinoshita, Takeo Nakayama, Masaharu Tsubokura.

  Stable Iodine Distribution among Children after the 2011 Fukushima Nuclear Disaster in Japan: An Observational Study.
  J Clin Endocrinol Metab.2019 May 1;104(5):1658-1666.

• Yamashita C, Otsuka A, Nomura M, Honda T, Kabashima K.

  Successful treatment of metastatic mucosal melanoma with a Del579 c-KIT mutation by imatinib after treatment of anti-PD-1 antibody.

  J Eur Acad Dermatol Venereol. 2019 Mar;33(3):e92-e93.

• Tamaoki M, Amanuma Y, Ohashi S, Muto M.

  Alcohol-induced DNA injury in esophageal squamous cell carcinoma.

  Alcoholic/Non-Alcoholic Digestive Diseases 2019 p3-12

• Kondo T, Nomura M, Otsuka A, Nonomura Y, Kaku Y, Matsumoto S, Muto M.

  Predicting marker for early progression in unresectable melanoma treated with nivolumab.

  Int J Clin Oncol 2019 Mar;24(3):323-327.

• Nishino H, Hatano E, Okuno M, Toda R, Seo S, Taura K, Horimatsu T, Kanai M, Hasegawa S, Matsumoto S, Sakai Y, Uemoto S.

  Clinical Practice of Postoperative Adjuvant Chemotherapy in Patients with Colorectal Liver Metastases: Impact of the Completion for Six Months.

  Am Surg. 2019 Feb 1;85(2):e111-e114.

• Koyama T, Nomura M, Doi K, Tateya I, Muto M.
  Re-introducing the same chemotherapy after exposure to anti-PD-1 therapy.
  Int Cancer Conf J. 2019 Feb 12;8(2):86-88.

• Yoshitaka Nishikawa, Masaharu Tsubokura, Yoshimitsu Takahashi, Shuhei Nomura, Akihiko Ozaki, Yuko Kimura, Tomohiro Morita, Toyoaki Sawano, Tomoyoshi Oikawa, Takeo Nakayama.
  Change of access to emergency care in a repopulated village after the 2011 Fukushima nuclear disaster: A retrospective observational study.
  BMJ Open.2019 Feb 9;9(2):e023836.

• Mizumoto A, Ohashi S, Kamada M, Saito T, Nakai Y, Baba K, Hirohashi K, Mitani Y, Kikuchi O, Matsubara J, Yamada A, Takahashi T, Lee H, Okuno Y, Kanai M, Muto M.

  Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.

  J Gastroenterol. 2019 Aug;54(8):687-698.

• Ioka T, Ueno M, Ueno H, Park JO, Chang HM, Sasahira N, Kanai M, Chung IJ, Ikeda M, Nakamori S, Mizuno N, Omuro Y, Yamaguchi T, Hara H, Sugimori K, Furuse J, Maguchi H, Furukawa M, Fukuzawa K, Kim JS, Yukisawa S, Takeuchi M, Okusaka T, Boku N, Hyodo I.

  TAS-118 (S-1 plus leucovorin) versus S-1 in patients with gemcitabine-refractory advanced pancreatic cancer: a randomised, open-label, phase 3 study (GRAPE trial).

  Eur J Cancer. 2019 Jan;106:78-88.

• Yokoyama A, Kakiuchi N, Yoshizato T, Nannya Y, Suzuki H, Takeuchi Y, Shiozawa Y, Sato Y, Aoki K, Kim SK, Fujii Y, Yoshida K, Kataoka K, Nakagawa M, Inoue Y, Hirano T, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Nishikawa Y, Amanuma Y, Ohashi S, Aoyama I, Horimatsu T, Miyamoto S, Tsunoda S, Sakai Y, Narahara M, Brown JB, Sato Y, Sawada G, Mimori K, Minamiguchi S, Haga H, Seno H, Miyano S, Makishima H, Muto M, Ogawa S.

  Age-related remodelling of oesophageal epithelia by mutated cancer drivers.

  Nature. 2019 Jan;565(7739):312-317.

2018年

• Yamada K, Chigusa Y, Nomura M, Sakanaka K, Nakamura M, Yano S, Tsunoda S, Kondoh E, and Mandai M.

  A Case of Recurrent Esophageal Cancer Treated with Concurrent Chemoradiation Therapy in Pregnancy.

  Case Rep Obstet Gynecol. 2018 Dec 3;2018:1280582.

• Masuishi T, Taniguchi H, Eto T, Komori A, Mitani S, Hasegawa H, Narita Y, Ishihara M, Tanaka T, Kadowaki S, Ura T, Ando M, Tajika M, Nomura M, Sato Y, Mishima H, Muro K.

  Morphologic Response and Tumor Shrinkage as Early Predictive Markers in Unresectable Colorectal Liver Metastases.

  Anticancer Res. 2018 Nov;38(11):6501-6506.

• Yu Uneno, Manabu Muto,Tatsuya Morita.

  Integration of oncology and palliative care: less-mentioned issues and a Japanese perspective.

  Lancet Oncol. 2018 Nov;19(11):e570-e571.

• Karakasheva TA, Lin EW, Tang Q, Qiao E, Waldron TJ, Soni M, Klein-Szanto AJ, Sahu V, Basu D, Shinya Ohashi, Kiichiro Baba, Giaccone ZT, Walker SR, Frank DA, Wileyto EP, Long Q, Dunagin MC, Raj A, Diehl JA, Wong KK, Bass AJ, Rustgi AK.

  IL-6 mediates cross-talk between tumor cells and activated fibroblasts in the tumor microenvironment.

  Cancer Res. 2018 Sep 1;78(17):4957-4970.

• Takashi Kijima, Hiroshi Nakagawa, Masataka Shimonosono, Prasanna M Chandramouleeswaran, Takeo Hara, Varun Sahu, Yuta Kasagi, Osamu Kikuchi, Koji Tanaka, Veronique Giroux, Amanda B Muir, Kelly A Whelan, Shinya Ohashi, Seiji Naganuma, Andres J Klein-Szanto, Yoshiaki Shinden, Ken Sasaki, Itaru Omoto, Yoshiaki Kita, Manabu Muto, Adam J Bass, J Alan Diehl, Gregory G Ginsberg, Yuichiro Doki, Masaki Mori, Yasuto Uchikado, Takaaki Arigami, Narayan G Avadhani, Devraj Basu, Anil K Rustgi, Shoji Natsugoe.

  Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells

  Cell Mol Gastroenterol Hepatol. 2018 Sep 14;7(1):73-91.

• Sunami K, Takahashi H, Tsuchihara K, Takeda M, Suzuki T, Naito Y, Sakai K, Dosaka-Akita H, Ishioka C, Kodera Y, Muto M, Wakai T, Yamazaki K, Yasui W, Bando H, Fujimoto Y, Fukuoka S, Harano K, Kawazoe A, Kimura G, Koganemaru S, Kogawa T,Kotani D, Kuboki Y, Matsumoto H, Matsumoto S, Mishima S, Nakamura Y, Sawada K, Shingaki S, Shitara K, Umemoto K, Umemura S, Yasuda K, Yoshino T, Yamamoto N, Nishio K.

  Clinical practice guidance for next‐generation sequencing in cancer diagnosis and treatment (Edition 1.0)

  Cancer Sci. 2018 Sep;109(9):2980–2985.

• Fukuma S, Kimachi M, Omae K, Kataoka Y, Yamazaki H, Muto M, Akizawa T, Yanagita M, Fukuhara S.

  Dialysis physicians’ referral behaviors for hemodialysis patients suspected of having cancer: A vignette-based questionnaire study.

  PLoS One. 2018 Aug 15;13(8):e0202322.

• Yoshitaka Nishikawa, Yasuaki Ozawa, Masaharu Tsubokura, Akihiko Ozaki, Toyoaki Sawano, Tomohiro Morita, Naoto Yoshida and Fumio Fujii.

  Long-term vulnerability of access to hemodialysis facilities in repopulated areas after the Fukushima Nuclear Disaster: a case report

  Oxf Med Case Reports. 2018;7, 228–230

• Yoshitaka Nishikawa, Hideki Yokoi, Takaki Sakurai, Takahiro Horimatsu, and Shin’ichi Miyamoto.

  Lanthanum deposition in the gastric mucosa in a patient undergoing hemodialysis

  QJM. 2018 May 1;111(5):347-348.

• Yosuke Fujii, Yoshitaka Nishikawa, Motoo Nomura, Shin’ich Miyamto, Yu Uneno, Takahiro Horimatsu, and Manabu Muto.

  Readministration of Nivolumab after Persistent Immune-Related Colitis in a Patient with Recurrent Melanoma

  Intern Med. 2018 Apr 15;57(8):1173-1176.

• Yoshihide Mitsuda, Ken Morita, Gengo Kashiwazaki, Junichi Taniguchi, Toshikazu　Bando, Masahiro Hirata, Moeka Obara, Tatsuki R Kataoka, Manabu Muto,Yasufumi Kaneda, Tatsutoshi Nakahata, Pu Paul Liu, Souichi Adachi, Hiroshi Sugiyama and Yasuhiko Kamikubo.

  RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells.

  Sci Rep. 2018 Apr 23;8(1):6423.

• Tamaoki Masashi, Komatsuzaki Rie, Komatsu Masayuki, Minashi Keiko, Aoyagi Kazuhiko, Nishimura Takao, Chiwaki Fumiko, Hiroki Tomoko, Daiko Hiroyuki, Morishita Kazuhiro, Sakai Yoshiharu, Seno Hiroshi, Chiba Tsutomu, Muto Manabu, Yoshida Teruhiko, Sasaki Hiroki.

  Multiple roles of SIM2 in esophageal squamous cell carcinoma and its clinical implications

  Cancer Sci. 2018 Apr;109(4):1121-1134.

• Hiroki Nagai, Manabu Muto.

  Optimal management of immune-related adverse events resulting from treatment with immune checkpoint inhibitors: a review and update

  Int J Clin Oncol. 2018 Jun;23(3):410-420.

• Tomohiro Kondo, Masashi Kanai, Tadayuki Kou, Tomohiro Sakuma, Hiroaki Mochizuki,

  Mayumi Kamada, Masahiko Nakatsui, Norimitsu Uza, Yuzo Kodama,Toshihiko Masui,

  Kyoichi Takaori, Shigemi Matsumoto, Hidehiko Miyake, Yasushi Okuno and Manabu Muto.

  Association between homologous recombination repair gene mutations and response to oxaliplatin in pancreatic cancer.

  Oncotarget. 2018 Apr 13;9(28):19817-19825.

• Motoo Nomura, Atsushi Otsuka, Michio Yoshimura, Yumi Nonomura, Yo Kaku, Shigemi Matsumoto, Manabu Muto.

  Efficacy and safety of concurrent immunoradiotherapy in patients with metastatic melanoma after progression on nivolumab

  Cancer Chemother Pharmacol. 2018 May;81(5):823-827.

• Yamada A, Yu P, Lin W, Okugawa Y, Boland CR, Goel A.

  A RNA-Sequencing approach for the identification of novel long non-coding RNA biomarkers in colorectal cancer.

  Sci Rep. 2018 Jan 12;8(1):575.

• Kanesaka T, Uedo N, Yao K, Ezoe Y, Doyama H, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, Ishikawa H, Takeuchi Y, Arao M, Iwatsubo T, Iwagami H, Matsuno K, Muto M, Saito Y, Tomita Y.

  Multiple convex demarcation line for prediction of benign depressed gastric lesions in magnifying narrow-band imaging.

  Endosc Int Open. 2018 Feb;6(2):E145-E155.

• Hiromasa Yamamoto, Shinichi Toyooka, Takashi Ninomiya, Shigemi Matsumoto, Masashi Kanai, Shuta Tomida, Katsuyuki Kiura, Manabu Muto, Ken Suzawa, Patrice Desmeules, Mark G. Kris, Bob T. Li, Marc Ladanyi.

  Therapeutic potential of afatinib for cancers with ERBB2 (HER2) transmembrane domain mutations G660D and V659E

  Oncologist. 2018 Feb;23(2):150-154.

• Taro Funakoshi, Takahiro Horimatsu, Michio Nakamura, Koichi Shiroshita, Koichi Suyama, Masashi Mukoyama, Takuro Mizukami, Tsutomu Sakurada, Eishi Baba, Kazuhiko Tsuruya, Akira Nozaki, Kensei Yahata, Yukinori Ozaki, Yoshifumi Ubara, Hisateru Yasui, Akihiro Yoshimoto, Shingo Fukuma, Naoya Kondo, Takeshi Matsubara, Kazuo Matsubara, Shunichi Fukuhara, Motoko Yanagita, Manabu Muto.

  Chemotherapy in cancer patients undergoing hemodialysis: A nationwide study in Japan

  ESMO Open 2018 Feb 23;3(2):e000301.

2017年

• Yasumasa Ezoe, Junki Mizusawa, Hiroshi Katayama, Kozo Kataoka, Manabu Muto.

  An integrated analysis of hyponatremia in cancer patients receiving platinum-based or nonplatinum-based chemotherapy in clinical trials (JCOG1405-A)

  Oncotarget 2017 Dec 20;9(5):6595-6606.

• Tatsuya Miyazaki, Yuko Kitagawa, Hiroyuki Kuwano, Motoyasu Kusano, Tuneo Oyama, Manabu Muto, Hiroyuki Kato, Hiroya Takeuchi, Yasushi Toh, Yuichiro Doki, Yoshio Naomoto, Kenji Nemoto, Hisahiro Matsubara, Akio Yanagisawa, Takashi Uno, Ken Kato, Masahiro Yoshida, Hirofumi Kawakubo, Eisuke Booka, Osamu Kawamura, Minoru Fukuchi, Makoto Sakai, Makoto Sohda, Masanobu Nakajima.

  Decreased risk of esophageal cancer owing to cigarette and alcohol cessation in smokers and drinkers: a systematic review and meta-analysis

  Esophagus 2017 Oct;14: 290-302

• Nomura M, Otsuka A, Kondo T, Nagai H, Nonomura Y, Kaku Y, Matsumoto S, Muto M.

  Efficacy and safety of retreatment with nivolumab in metastatic melanoma patients previously treated with nivolumab

  Cancer Chemother Pharmacol 2017 Nov;80(5):999-1004.

• Ayaka Mizumoto, Shinya Ohashi, Kenshiro Hirohashi, Yusuke Amanuma, Tomonari Matsuda, Manabu Muto

  Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium.

  Int J Mol Sci 2017 Sep 10;18(9).

• Yu Uneno, Kei Taneishi, Masashi Kanai, Kazuya Okamoto, Yosuke Yamamoto, Akira Yoshioka, Shuji Hiramoto, Akira Nozaki, Yoshitaka Nishikawa, Daisuke Yamaguchi, Teruko Tomono, Masahiko Nakatsui Mika Baba, Tatsuya Morita, Shigemi Matsumoto, Tomohiro Kuroda, Yasushi Okuno, Manabu Muto.

  Development and Validation of a Set of Six Adaptable Prognosis Prediction (SAP) Models Based on Time-Series Real-World Big Data Analysis for Patients with Cancer Receiving Chemotherapy: A Multicenter Case Crossover Study.

  PLoS One. 2017 Aug 24;12(8):e0183291.

• Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Junichi Matsubara, Atsushi Yamada, Shin’ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa,Tsutomu Chiba, Hiroshi Seno, Manabu Muto.

  Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells

  J Exp Clin Cancer Res 2017 Aug 1;36(1):101.

• Peng Xue, Junjie Hang, Weiyi Huang, Shaobo Li, Ning Li, Yuzo Kodama, Shigemi Matsumoto, Kyoichi Takaori, Lifei Zhu, Masashi Kanai

  Validation of Lymphocyte to Monocyte Ratio As a Prognostic Factor in Advanced Pancreatic Cancer: An East Asian Cohort Study of Two Countries

  Pancreas 2017 Sep;46(8):1011-1017.

• Takahiro Horimatsu, Norisuke Nakayama, Toshikazu Moriwaki, Yoshinori Hirashima, Mikio Fujita, Masako Asayama, Ichiro Moriyama, Koji Nakashima, Eishi Baba, Hiroshi Kitamura, Takao Tamura, Ayumu Hosokawa, Kenichi Yoshimura, Manabu Muto.

  A phase II study of 5-fluorouracil/L-leucovorin/oxaliplatin (mFOLFOX6) in Japanese patients with metastatic or unresectable small bowel adenocarcinoma.

  Int J Clin Oncol 2017 Oct;22(5):905-912.

• Masashi Tamaoki, Yasumasa Ezoe1, Ikuo Aoyama, Takahiro Horimatsu, Shuko Morita, Shin’ichi Miyamoto, Shigemi Matsumoto, Tsutomu Chiba, and Manabu Muto.

  S-1 Salvage Chemotherapy for Esophageal Squamous Cell Carcinoma Refractory to the Standard Chemotherapy.

  J Cancer Sci Ther 2017;9(3):353-357.

• Kitayama H, Kondo T, Sugiyama J, Kurimoto K, Nishino Y, Hirayama M, Tsuji Y.

  Venous thromboembolism in hospitalized patients receiving chemotherapy for malignancies at Japanese community hospital: prospective observational study.

  BMC Cancer.2017 May 19;17(1):351.

• Kitayama H, Kondo T, Sugiyama J, Kurimoto K, Nishino Y, Kawada M, Hirayama M, Tsuji Y.

  High-sensitive troponin T assay can predict anthracycline- and trastuzumab-induced cardiotoxicity in breast cancer patients.

  Breast Cancer. 2017 Nov;24(6):774-782.

• Yoshitaka Nishikawa, Masashi Kanai, Maiko Narahara,Akiko Tamon, JB Brown , Kei Taneishi, Masahiko Nakatsui, Kazuya Okamoto, Yu Uneno, Daisuke Yamaguchi, Teruko Tomono,Yukiko Mori, Shigemi Matsumoto, Yasushi Okuno, and Manabu Muto.

  Association between UGT1A1*28*28 genotype and lung cancer in the Japanese population

  Int J Clin Oncol.2017 Apr;22(2):269-273.

• Ito T, Honma Y, Hijioka S, Kudo A, Fukutomi A, Nozaki A, Kimura Y, Motoi F, Isayama H, Komoto I, Hisamatsu S, Nakajima A, Shimatsu A.

  Phase II study of lanreotide autogel in Japanese patients with unresectable or metastatic well-differentiated neuroendocrine tumors.

  Invest New Drugs. 2017 Aug;35(4):499-508.

• Aizawa R, Matsumoto S, Uneno Y, Nishikawa Y, Ozaki Y, Mori Y, Kanai M, Ishida Y, Sakanaka K, Hiraoka M, Muto M.

  Severe esophagitis associated with cytomegalovirus during concurrent chemoradiotherapy for esophageal cancer.

  Jpn J Clin Oncol. 2017 Sep 1;47(9):885-888.

• Nishimura T, Tamaoki M, Komatsuzaki R, Oue N, Taniguchi H, Komatsu M, Aoyagi K, Minashi K, Chiwaki F, Shinohara H, Tachimori Y, Yasui W, Muto M, Yoshida T, Sakai Y, Sasaki H.

  SIX1 maintains tumor basal cells via transforming growth factor-β pathway and associates with poor prognosis in esophageal cancer.

  Cancer Sci. 2017 Feb;108(2):216-225.

• Ikuo Aoyama, Shinya Ohashi, Yusuke Amanuma, Kenshiro Hirohashi, Ayaka Mizumoto, Makiko Funakoshi, Mihoko Tsurumaki, Yukie Nakai, Katsuyuki Tanaka, Mariko Hanada, Aki Uesaka, Tsutomu Chiba, Manabu Muto.

  Establishment of a quick and highly accurate breath test for ALDH2 genotyping

  Clin Transl Gastroenterol. 2017 Jun 8;8(6):e96.

• Tadayuki Kou, Masashi Kanai, Yoshihiro Yamamoto, Mayumi Kamada, Masahiko Nakatsui, Tomohiro Sakuma, Hiroaki Mochizuki, Akinori Hiroshima, Aiko Sugiyama, Eijiro Nakamura, Hidehiko Miyake, Sachiko Minamiguchi, Kyoichi Takaori, Shigemi Matsumoto, Hironori Haga, Hiroshi Seno, Shinji Kosugi, Yasushi Okuno, Manabu Muto.

  Clinical Sequencing Using a Next-Generation Sequencing-Based Multiplex Gene Assay in Patients with Advanced Solid Tumors

  Cancer Sci. 2017 Jul;108(7):1440-1446.

• Nagayama S, Hasegawa S, Hida K, Kawada K, Hatano E, Nakamura K, Seo S, Taura K, Yasuchika K, Matsuo T, Zaima M, Kanazawa A, Terajima H, Tada M, Adachi Y, Nishitai R, Manaka D, Yoshimura T, Doi K, Horimatsu T, Mitsuyoshi A, Yoshimura K, Niimi M, Matsumoto S, Sakai Y, Uemoto S.

  Multi-institutional phase II study on the feasibility of liver resection following preoperative mFOLFOX6 therapy for resectable liver metastases from colorectal cancers.

  Int J Clin Oncol 2017 Apr;22(2):316-323.

• Yano T, Yoda Y, Nomura S, Toyosaki K, Hasegawa H, Ono H, Tanaka M, Morimoto H, Horimatsu T, Nonaka S, Kaneko K, Sato A.

  Prospective trial of biodegradable stents for refractory benign esophageal strictures after curative treatment of esophageal cancer.

  Gastrointest Endosc. 2017 Sep;86(3):492-499.

• Hirakawa H, Nakashima C, Nakamura T, Masuda M, Funakoshi T, Nakagawa S, Horimatsu T, Matsubara K, Muto M, Kimura S, Sueoka-Aragane N.

  Chemotherapy for primary mediastinal yolk sac tumor in a patient undergoing chronic hemodialysis: a case report.

  J Med Case Rep. 2017 Feb 16;11(1):43

• Nomura M, Kato K, Ando N, Ohtsu A, Muro K, Igaki H, Abe T, Takeuchi H, Daiko H, Gotoh M, Kataoka K, Wakabayashi M, Kitagawa Y.

  Comparison between neoadjuvant chemotherapy followed by surgery and definitive chemoradiotherapy for overall survival in patients with clinical Stage II/III esophageal squamous cell carcinoma (JCOG1406-A).

  Jpn J Clin Oncol. 2017 Mar 17:1-7.

• Akira Yokoyama, Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Kazuhiro Kaneko, Ichiro Oda, Yuichi Shimizu, Hisashi Doyama, Tomoyuki Koike, Kohei Takizawa, Motohiro Hirao, Hiroyuki Okada, Takako Yoshii, Kazuo Konishi, Takenori Yamanouchi, Takashi Tsuda, Tai Omori, Nozomu Kobayashi, Haruhisa Suzuki, Satoshi Tanabe, Keisuke Hori, Norisuke Nakayama, Hirofumi Kawakubo, Hideki Ishikawa, Manabu Muto.

  Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer.

  PLoS One. 2017 Apr 6;12(4):e0175182

• Tomonori Yano, Hiroi Kasai, Takahiro Horimatsu, Kenichi Yoshimura, Satoshi,Teramukai, Satoshi Morita, Harue Tada, Yoshinobu Yamamoto, Hiromi Kataoka,Naomi Kakushima, Ryu Ishihara, Hajime Isomoto, Manabu Muto

  A multicenter phase II study of salvage photodynamic therapy using talaporfin sodium (ME2906) and a diode laser (PNL6405EPG) for local failure after chemoradiotherapy or radiotherapy for esophageal cancer

  Oncotarget 2017 Mar 28;8(13):22135-22144.

• Seiji Ishikawa, Ichiro Tateya, Takahiro Hayasaka, Satoru Shinriki, Noritaka Masaki, Shigeru Hirano, Morimasa Kitamura, Manabu Muto, Shuko Morita, Mitsutoshi Setou, Juichi Ito.

  The Distribution of Phosphatidylcholine Species in Superficial-Type Pharyngeal Carcinoma

  Biomed Res Int.2017;2017:5387913.

• Yoshitaka Nishikawa, Taro Funakoshi, Takahiro Horimatsu, Shinichi Miyamoto, Takeshi Matsubara, Motoko Yanagita, Shunsaku Nakagawa, Atsushi Yonezawa, Kazuo Matsubara, Manabu Muto.

  Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia

  Cancer Chemother Pharmacol. 2017 Mar;79(3):629-633

• Deguchi Y, Okabe H, Oshima Y, Hisamori S, Minamiguchi S, Muto M, Sakai Y.

  PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma

  Gastric Cancer. 2017 May;20(3):416-427.

• Kenshi Yao, Noriya Uedo, Manabu Muto, Hideki Ishikawa

  Development of an e-learning system for teaching endoscopists how to diagnose early gastric cancer: basic principles for improving early detection

  Gastric Cancer 2017 Mar;20(Suppl 1):28-38.

• Yamamura K, Otsuka A, Kaku Y, Seidel JA, Nomura M, Nagai H, Matsumoto S, Kabashima K.

  Dermoscopic changes in malignant melanoma after successful treatment with nivolumab: A case report

  J Dermatol. 2017 May;44(5):547-548

• Manabu Muto

  Biobank and informatics for cancer projects and clinical sequencing at Kyoto University Cancer Center

  Clin Eval 45(1) 2017 189-193

2016年

• Sano Y, Tanaka S, Kudo S, Saito S, Matsuda T, Wada Y, Fujii T, Ikematsu H, Uraoka T, Kobayashi N, Nakamura H, Hotta K,Horimatsu T, Sakamoto N, Fu KI, Tsuruta O, Kawano H, Kashida H, Takeuchi Y, Machida H, Kusaka T, Yoshida N, Hirata I,Terai T, Yamano HO, Kaneko K,Nakajima T, Sakamoto T, Yamaguchi Y, Tamai N, Nakano N, Hayashi N, Oka S, Iwatate M, Ishikawa H, Murakami Y, Yoshida S, Saito Y

  Narrow-band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team.

  Dig Endosc. 2016 Jul;28(5):526-33.

• Maeda A, Ura T, Asano C, Haegawa I, Nomura M, Komori A, Narita Y, Taniguchi H, Kadowaki S, Muro K, Horio Y, Yoshida T, Oze I, Kajita M, Mizutani A.

  A phase II trial of prophylactic olanzapine combined with palonosetron and dexamethasone for preventing nausea and vomiting induced by cisplatin

  Asia Pac J Clin Oncol 2016 Sep;12(3):254-8.

• Koji Tanaka, Kelly A Whelan,Prasanna M Chandramouleeswaran, Shingo Kagawa, Sabrina L Rustgi, Chiaki Noguchi, Manti Guha,Satish Srinivasan, Yusuke Amanuma, Shinya Ohashi, Manabu Muto,Andres J Klein-Szanto, Eishi Noguchi,Narayan G Avadhani.

  ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds

  Am J Cancer Res. 6(4):781-796, 2016.

• Yoshitaka Nishikawa, Shin’ichi Miyamoto, Takahiro Horimatsu, Hiroshi Okabe, Manabu Muto.

  Esophageal rupture associated with colonoscopy preparation.

  J Am Geriatr Soc. Mar;64(3):682-3 2016

• Nishiakawa Y, Sakurai T, Miyamoto S

  Multiple White Plaques in the Body of the Stomach in a Patient Undergoing Hemodialysis

  Gastroenterology 151(1):e18-e19, 2016.

• Kohei Takizawa, Hiroyuki Ono, Yorimasa Yamamoto, Hitoshi Katai, Shinichiro Hori, Tomonori Yano, Eiji Umegaki, Shunya Sasaki, Toshiro Iizuka, Kei Kawagoe, Tadakazu Shimoda, Manabu Muto, Mitsuru Sasako.

  Incidence of lymph node metastasis in intramucosal gastric cancer measuring ≤30 mm, with ulceration; mixed, predominantly differentiated-type histology; and no lymphovascular invasion: a multicenter retrospective study

  Gastric Cancer 19(4):1144-1148, 2016.

• Kato H, Kitagawa Y, Kuwano　H, Toh Y, Kusano M, Oyama T, Muto M, Takeuchi H, Doki Y, Naomoto Y, Nemoto K, Matsubara H, Miyazaki T, Yanagisawa A, Uno T, Kato K, Yoshida M, Kawakubo H, Booka E, Nakajima M, Kaneko K, Shiotani A

  Neo-adjuvant therapy or definitive chemoradiotherapy can improve laryngeal preservation rates in patients with cervical esophageal cancer. A Japanese nationwide survey

  Esophagus 13(3):276-282, 2016

• Tateya I, Muto M, Morita S, Miyamoto S, Hayashi T, Funakoshi M, Aoyama, I Higuchi H, Hirano　S, Kitamura　M, Ishikawa　S, Kishimoto　Y, Morita　M, Ito　J

  Endoscopic laryngo-pharyngeal surgery for superficial laryngopharyngeal cancer.

  Surg Endosc. 30(1):323-329, 2016.

• Yuichiro Kitai, Takeshi Matsubara, Taro Funakoshi, Takahiro Horimatsu, Manabu Muto, Motoko Yanagita

  Cancer screening and treatment in patients with end-stage renal disease: remaining issues in the field of onco-nephrology ; Invited review article by Japanese Society for Dialysis Therapy

  Renal Replacement Therapy 2：33, 2016

• Kakushima N, Hori K, Ono H, Horimatsu T, Uedo N, Ohata K, Doyama H, Kaneko K, Oda I, Hikichi T, Kawahara Y, Niimi K, Takaki Y, Mizuno M, Yazumi S, Hosokawa A, Imagawa A, Niimi M, Yoshimura K, Muto M

  Proton pump inhibitor after endoscopic resection for esophageal squamous cell cancer: multicenter prospective randomized controlled trial

  J Gastroenterol. 51(2):104-111, 2016.

• Yukiko Mori, Satoshi Nagayama, Jun-ichiro Kawamura, Suguru Hasegawa, Eiji Tanaka, Hiroshi Okabe, Megumi Takeuchi, Makoto Sonobe, Shigemi Matsumoto, Masashi Kanai, Manabu Muto, Tsutomu Chiba, Yoshiharu Sakai.

  A retrospective analysis on the utility and complications of upper arm ports in 433 cases at a single institute.

  Int J Clin Oncol 21(3):474-482, 2016.

• Kou T, Kanai M, Yamamoto M, Xue P, Mori Y, Kudo Y, Kurita A, Uza N, Kodama Y, Asada M, Kawaguchi M, Masui T, Mizumoto M, Yazumi S, Matsumoto S, Takaori K, Morita S, Muto M, Uemoto S, Chiba T.

  Prognostic model for survival based on readily available pretreatment factors in patients with advanced pancreatic cancer receiving palliative chemotherapy

  Int J Clin Oncol 21(1):118-125, 2016.

• Koichi Inoue, Motoo Nomura

  Assay for Fentanyl

  In Victor R. Preedy (ed): The Neuropathology of Drug Addictions and Substance Misuse Volume 3, 1st Edition. Netherlands, Amsterdam, Elsevier B.V. 2016;619-630.

• Toh Y, Kitagawa Y, Kuwano H, Kusano M, Oyama T, Muto M, Kato H, Takeuchi H, Doki Y, Nomoto Y, Nemoto K, Matsubar H, Miyazaki T, Yanagisawa A, Uno T, Kato K, Yoshidam M, Kawakubo H, Booka E.

  A Nation-wide Survey of Follow-up Strategies for Esophageal Cancer Patients after a Curative Esophagectomy or a Complete Response by Definitive Chemoradiotherapy in Japan

  Esophagus 13(2):173-181, 2016

• Katada C, Yokoyama T, Yano T, Kaneko K, Oda I, Shimizu Y, Doyama H, Koike T, Takizawa K, Hirao M, Okada H, Yoshii T, Konishi K, Yamanouchi T, Tsuda T, Omori T, Kobayashi N, Shimoda T, Ochiai A, Amanuma Y, Ohashi S, Matsuda T, Ishikawa H, Yokoyama A, Muto M.

  Alcohol consumption and multiple dysplastic lesions increase risk of squamous cell carcinoma in the esophagus, head, and neck

  Gastroenterology 151(5):860-869, 2016.

• Manabu Muto, Kenshi Yao, Mitsuru Kaise, Mototsugu Kato, Noriya Uedo, Kazuyoshi Yagi, Hisao Tajiri

  Magnigying endoscopy simple diagnostic algorithm for early gastric cancer

  Dig Endosc 28(4):379-393, 2016.

• Ichiro Tateya, Shuko Morita, Seiji Ishikawa, Manabu Muto, Shigeru Hirano, Yo Kishimoto, Nao Hiwatashi, Juichi Ito.

  Voice outcome in patients treated with endoscopic laryngopharyngeal surgery for superficial hypopharyngeal cancer

  Clin Exp Otorhinolaryngol. 9(1):70-74, 2016.

• Ichiro Tateya, Akihiro Shiotanik Yasuto Satou, Masayuki Tomifuji, Shuko Morita, Manabu Muto, Juichi Ito

  Transoral surgery for laryngo-pharyngeal cancer-The paradigm shift of the head and cancer treatment

  Auris Nasus Larynx 43(1):21-32, 2016.

• Nomura M, Iwasa S, Tsushima T, Kato K, Yasui H, Boku N, Muto M, Muro K.

  Active salvage chemotherapy versus best supportive care for patients with recurrent or metastatic squamous cell carcinoma of the esophagus refractory or intolerable to fluorouracil, platinum, and taxane.

  Cancer Chemother Pharmacol. 2016 Dec;78(6):1209-1216.

• Yu Uneno, Akira Yokoyama, Yoshitaka Nishikawa, Taro Funakoshi, Yoshinao Ozaki, Ikuo Aoyama, Kiichiro Baba, Daisuke Yamaguchi, Shuko Morita, Yukiko Mori, Masashi Kanai, Hisanori Kinoshita, Takeshi Inoue, Nobukatsu Sawamoto, Riki Matsumoto, Shigemi Matsumoto, Manabu Muto.

  Paraneoplastic limbic encephalitis in human epidermal growth factor receptor-2-positive gastric cancer patient treated with trastuzumab-combined chemotherapy: case report and literature review.

  Internal Medicine 55(18):2605-2609, 2016.

• Yoshitaka Nishikawa, Hirokazu Higuchi, Osamu Kikuchi, Yasumasa Ezoe, Ikuo Aoyama, Atsushi Yamada, Masataka Kanki, Shuhei Nomura, Motoo Nomura, Takahiro Horimatsu and Manabu Muto.

  Factors affecting dilation force in balloon dilation of severe esophageal strictures: an experiment using an artificial stricture model

  Surgical Endoscopy 30(10):4315-4320, 2016.

• Okuno M, Hatano E, Kasai Y, Nishio T, Seo S, Taura K, Yasuchika K, Nitta T, Mori A, Okajima H, Kaido T, Hasegawa S, Matsumoto S, Sakai Y, Uemoto S.

  Feasibility of the liver-first approach for patients with initially unresectable and not optimally resectable synchronous colorectal liver metastases.

  Surg Today (2016) 46:721–728

• Hironaka S, Sugimoto N, Yamaguchi K, Moriwaki T, Komatsu Y, Nishina T, Tsuji A, Nakajima TE, Gotoh M, Machida N, Bando H, Esaki T, Emi Y, Sekikawa T, Matsumoto S, Takeuchi M, Boku N, Baba H, Hyodo I.

  S-1 plus leucovorin versus S-1 plus leucovorin and oxaliplatin versus S-1 plus cisplatin in patients with advanced gastric cancer: a randomised, multicentre, open-label, phase 2 trial.

  The Lancet. Oncology,17,1,99-108

• Kondo T, Kitayama H, Sugiyama J, Hirayama M, Suzuki Y, Oyamada Y, Tsuji Y.

  Conversion therapy of gastric cancer with massive malignant ascites and ovarian metastases by systemic and intraperitoneal chemotherapy.

  Mol Clin Oncol.5:740-744, 2016.

• Kitayama H, Kondo T, Sugiyama J, Hirayama M, Oyamada Y, Tsuji Y.

  Conversion therapy for pancreatic cancer having peritoneal metastases by intravenous and intraperitoneal paclitaxel with S-1.

  Mol Clin Oncol.5:779-782, 2016.

• Kitayama H, Kondo T, Sugiyama J, Hirayama M, Oyamada Y, Tsuji Y.

  Paraneoplastic erythrocytosis of colon cancer, with serum erythropoietin within the normal reference

  Am J Case Rep.17:417-420, 2016.

• Kitayama H, Yokota T, Kondo T, Sugiyama J, Hirayama M, Oyamada Y, Tsuji Y.

  Unusual Development of Pulmonary Tumor Embolism from Controlled Liver Metastases of Transitional Cell Carcinoma

  An Autopsy Case. Intern Med. 55:2453-1456, 2016.

• Ishizu S, Setoyama T, Ueo T, Ueda Y, Kodama Y, Ida H, Kawaguchi Y, Yoshizawa A, Chiba T, Miyamoto S.

  Concomitant case of intraductal papillary mucinous neoplasm of the pancreas and functioning pancreatic neuroendocrine tumor (Vasoactive intestinal polypeptide-producing tumor) first report.

  Pancreas 2016; 45: e24-e25.

• Kanai M, Kawaguchi T, Kotaka M, Shinozaki K, Touyama T, Manaka D, Ishigure K, Hasegawa J, Munemoto Y, Matsui T, Takagane A, Ishikawa H, Matsumoto S, Sakamoto J, Saji S, Yoshino T, Ohtsu A, Watanabe T, Matsuda F.

  Large-scale prospective pharmacogenomics study of oxaliplatin-induced neuropathy in colon cancer patients enrolled in the JFMC41-1001-C2 (JOIN Trial).

  Ann Oncol. 2016 Jun;27(6):1143-8.

• Hamada K, Takeuchi Y, Ishikawa H, Tonai Y, Matsuura N, Ezoe Y, Ishihara R, Tomita Y, Iishi H

  Feasibility of Cold Snare Polypectomy for Multiple Duodenal Adenomas in Patients with Familial Adenomatous Polyposis: A Pilot Study

  Dig Dis Sci. 2016 Sep;61(9):2755-9.

• Katsuyuki Sakanaka, Manabu Muto, et al.
  Identification of a Predictive Factor for Distant Metastasis in Esophageal Squamous Cell Carcinoma after Definitive Chemoradiotherapy.
  Int J Clin Oncol. 2016 Oct;21(5):899-908.

• Motoo Nomura, Isao Oze, Takeshi Kodaira, Tetsuya Abe, Azusa Komori, Yukiya Narita, Toshiki Masuishi, Hiroya Taniguchi, Shigenori Kadowaki, Takashi Ura, Masashi Andoh, Hiroyuki Tachibana, Norihisa Uemura, Masahiro Tajika, Yasumasa Niwa, Manabu Muto, Kei Muro.

  Comparison between surgery and definitive chemoradiotherapy for patients with resectable esophageal squamous cell carcinoma: a propensity score analysis

  Int J Clin Oncol. 2016 Oct;21(5):890-898.　

• Osamu Kikuchi, Shinya Ohashi, Tomohisa Horibe, Masayuki Kohno, Yukie Nakai, Shin’ichi Miyamoto, Tsutomu Chiba, Manabu Muto, and Koji Kawakami.

  Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma

  Sci Rep. 2016 Mar 9;6:22452

• Tadayuki Kou, Masashi Kanai, Shigemi Matsumoto, Yasushi Okuno, Manabu Muto.

  The possibility of clinical sequencing in the management of cancer.

  Jpn J Clin Oncol 46(5):399-406,2016.

2015年

• Tanaka Y, Aoyagi K, Minashi K, Komatsuzaki R, Komatsu M, Chiwaki F, Tamaoki M, Nishimura T, Takahashi N, Oda I, Tachimori Y, Arao T, Nishio K, Kitano S, Narumi K, Aoki K, Fujii S, Ochiai A, Yoshida T, Muto M, Yamada Y, Sasaki H.

  Discovery of a Good Responder Subtype of Esophageal Squamous Cell Carcinoma with Cytotoxic T-Lymphocyte Signatures Activated by Chemoradiotherapy.

  PLoS One. 2015 Dec 1;10(12):e0143804.

• Shinya Ohashi, Shin’ichi Miyamoto, Osamu Kikuchi, Tomoyuki Goto, Yusuke Amanuma, and Manabu Muto.

  Recent Advances from Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma.

  Gastroenterology 2015 Dec;149(7):1700-15.

• Horimatsu T, Miyamoto S, Mashimo Y, Okabe H, Mikami Y, Chiba T, Muto M.

  Pseudo-Meigs’ Syndrome Caused by a Krukenberg Tumour of Gastric Cancer.

  Intern Med. 2015;54(20):2595-7.

• Setoyama T, Miyamoto S, Nikaido M, Muto M, Chiba T.

  Instability of IGF-IGFBP complex as a cause of the different performance of serum and EDTA-plasma after storage: EDTA-plasma is preferable for evaluating bioactive IGF especially in the mouse.

  Growth Horm IGF Res. 2015 Oct;25(5):227-31.

• Yusuke Amanuma, Shinya Ohashi, Yoshiro Itatani, Mihoko Tsurumaki, Shun Matsuda, Osamu Kikuchi, Yukie Nakai, Shin’ichi Miyamoto, Tsunehiro Oyama, Toshihiro Kawamoto, Kelly Whelan, Hiroshi Nakagawa, Tsutomu Chiba, Tomonari Matsuda, and Manabu Muto.

  Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium.

  Scientific Reports 2015 Sep 16;5:14142.

• Yamada A, Horimatsu T, Okugawa Y, Nishida N, Honjo H, Ida H, Kou T, Kusaka T, Sasaki Y, Makato Y, Higurashi T, Yukawa N, Amanuma Y, Kikuchi O, Muto M, Ueno Y, Nakajima A, Chiba T, Boland CR, Goel A.

  Serum miR-21, miR-29a and miR-125b are promising biomarkers for the early detection of colorectal neoplasia.

  Clin Cancer Res. 2015 Sep 15;21(18):4234-42.

• Sato F, Kubota Y, Natsuizaka M, Maehara O, Hatanaka Y, Marukawa K, Terashita K, Suda G, Ohnishi S, Shimizu Y, Komatsu Y, Ohashi S, Kagawa S, Kimugasa H, Whelan KA, Nakagawa H, Sakamoto N.

  EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition.

  Cancer Biol Ther. 2015, 16(6) : 933-40

• Fujiwara Y, Kobayashi S, Nagano H, Kanai M, Hatano E, Toyoda M, Ajiki T, Takashima Y, Yoshimura K, Hamada A, Minami H, Ioka T.

  Pharmacokinetic Study of Adjuvant Gemcitabine Therapy for Biliary Tract Cancer following Major Hepatectomy (KHBO1101).

  PLoS One. 2015 Dec 3;10(12):e0143072.

• Kishi T, Nakamura A, Itasaka S, Shibuya K, Matsumoto S, Kanai M, Kodama Y, Takaori K, Mizowaki T, Hiraoka M.

  Pretreatment C-reactive protein level predicts outcome and patterns of failure after chemoradiotherapy for locally advanced pancreatic cancer.

  Pancreatology. 2015 Nov-Dec;15(6):694-700

• Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, Hosoe Y, Morita S, Yokode M, Shimizu A, Honjo T, Konishi I.

  Safety and anti-tumor activity of anti-PD-1 antibody (nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer.

  J Clin Oncol. 2015 Dec 1;33(34):4015-22.

• Hatano E, Kanai M, Nagano H, Ioka T.

  Clinical study of new chemotherapy regimen for biliary tract cancer.

  Nihon Rinsho. 2015 Mar;73 Suppl 3:805-8.

• Kitayama H, Tsuji Y, Sugiyama J, Doi A, Kondo T, Hirayama M.

  Efficacy of palonosetron and 1-day dexamethasone in moderately emetogenic chemotherapy compared with fosaprepitant, granisetron, and dexamethasone: a prospective randomized crossover study.

  Int J Clin Oncol. 20:1051- 1056, 2015.

• Kanai M, Hatano E, Kobayashi S, Fujiwara Y, Marubashi S, Miyamoto A, Shiomi H, Kubo S, Ikuta S, Yanagimoto H, Terajima H, Ikoma H, Sakai D, Kodama Y, Seo S, Morita S, Ajiki T, Nagano H, Ioka T.

  A multi-institution phase II study of gemcitabine/cisplatin/S-1 (GCS) combination chemotherapy for patients with advanced biliary tract cancer (KHBO 1002).

  Cancer Chemother Pharmacol. 2015 Feb; 75(2):293-300.

• Nomura M, Oze I, Abe T, Komori A, Narita Y, Masuishi T, Taniguchi H, Kadowaki S, Ura T, Andoh M, Kawai R, Uemura N, Ishihara M, Tanaka T, Tajika M, Niwa Y, Muro K, Muto M.

  Impact of docetaxel in addition to cisplatin and fluorouracil as neoadjuvant treatment for resectable stage III or T3 esophageal cancer: a propensity score-matched analysis.

  Cancer Chemother Pharmacol 2015 Aug;76(2):357-63.

• Osamu kikuchi, Shinya Ohashi, Yukie Nakai, Shunsaku Nakagawa, Kazuaki Matsuoka, Takashi Kobunai, Teiji Takechi, Yusuke Amanuma, Masahiro Yoshioka, Tomomi Ida, Yoshihiro Yamamoto, Yasushi Okuno,Shin’ichi Miyamoto, Hiroshi Nakagawa, Kazuo Matsubara, Tsutomu Chiba, and Manabu Muto.

  Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression.

  American Journal of Cancer Research 2015 Jul 15;5(8):2431-40. eCollection 2015.

• Ichiro Tateya, Shuko Morita, Manabu Muto, Shinichi Miyamoto, Tomomasa Hayashi, Makiko Funakoshi, Ikuo Aoyama, Shigeru Hirano, Morimasa Kitamura, Seiji Ishikawa, Yo Kishimoto, Mami Morita, Patnarin Mahattanasakul, Satoshi Morita, Juishi Ito

  Magnifying endoscope with NBI topredict the depth of invasion in laryngo-pharyngeal cancer

  Laryngoscope 125(5):1124-1129, 2015.

• Kozo Katanaoka, Ikuo Aoyama, Junnki Mizusawa, Junko Eba, Keiko Minashi, Tomonori Yano Masaki Tanaka, Noboru Hanaoka, Hiroshi Katayama, Kohei Takizawa, Haruhiko Fukuda, Manabu Muto on behalf of the Gastrointestinal Endoscopy Study Group(GIESG)of the Japan Clinical Oncology Group.

  A randomized controlled Phase II/III study comparing endoscopic balloon dilation combined with steroid injection versus radial incision and cutting combined with steroid injection for refractory anastomotic stricture after esophagectomy:

  Jpn J Clin Oncol. 2015 Apr;45(4):385-9.

• Tomonori Mizutani, Masaki Tanaka, Junko Eba, Junki Mizusawa, Haruhiko Fukuda, Nonobu Hanaoka, Manabu Takeuchi, Ikuo Aoyama, Takashi Kojima, Kohei Takizawa, Hiroyuki Ono, Manabu Muto.

  A Phase III study of oral steroid administration versus local steroid injection therapy for the prevention of esophageal stricture after endoscopic submucosal dissection (JCOG1217, Steroid EESD P3)

  Jpn J Clin Oncol　45(11):1087-1090, 2015.

• Hatano E, Okuno M, Nakamura K, Ishii T, Seo S, Taura K, Yasuchika K, Yazawa T, Zaima M, Kanazawa A, Terajima H, Kaihara S, Adachi Y, Inoue N, Furumoto K, Manaka D, Tokka A,　Furuyama H, Doi K, Hirose T,　Horimatsu T, Hasegawa S, Matsumoto S, Sakai Y, Uemoto S.

  Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K-ras status for unresectable colorectal liver metastasis (BECK study)

  J Hepatobiliary Pancreat Sci　22(8):634-645, 2015

• Horimatsu T, Sano Y, Tanaka S, Kawamura T, Saito S, Iwatate M, Oka S, Uno K, Yoshimura K, Ishikawa H, Muto M, Tajiri H.

  Next-generation narrow band imaging system for colonic polyp detection: a prospective multicenter randomized trial

  Int J Colorectal Dis. 30(7):947-54

• Ishikawa S, Tateya I, Hayasaka T, Masak Ni, Hirano S, Kitamura M, Muto M, Morita S, Setou M, Ito J.

  Phosphatidylcholine with arachidonic acid was increased in the submucosal microinvasive region of hypopharyngeal carcinoma

  Head Neck.2015

• Nikaido M, Miyamoto S, Iinuma S.

  Prevention of gastric volvulus-induced recurrent acute pancreatitis by percutaneous endoscopic gastropexy

  Gastroenterol Hepatol 13(2):e11-e12:2015.

• Hiroyuki Kuwano, Yasumasa Nishimura, Tsuneo Oyama, Hiroyuki Kato, Yuko Kitagawa, Motoyasu Kusano, Hideo Shimada, Hiroya Takiuchi, Yasushi Toh, Yuichiro Doki, Yoshio Naomoto, Hisahiro Matsubara, Tatsuya Miyazaki, Manabu Muto, Akio Yanagisawa

  Guidelines for diagnosis and treatment of caarcinoma of the esophagus April 2012 edited by the Japan Esophageal Society

  Esophagus 12:1-30,2015

• Kanesaka　T, Uedo N, Yao K, Ezoe Y, Doyama H, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, Ishikawa H, Kato M, Takeuchi Y, Muto M, Saito Y.

  A significant feature of microvessels in magnifying narrow-band imaging for diagnosis of early gastric cancer

  Endosoc Int Open 2015 3(6):E590-E596, 2015.

• Satake H, Yano T, Muto M, Minashi K, Yoda Y, Kojima T, Oono Y, Ikematsu H, Aoyama I, Morita S, Miyamoto S, Fujii S, Yoshizawa A, Ochiai A, Hayashi R, Kaneko K.

  Clinical outcome after endoscopic resection for superficial pharyngeal squamous cell carcinoma invading the subepithelial layer

  Endoscopy 47(1):11-18,2015

• Hayashi K, Fujiwara Y, Nomura M, Kamata M, Kojima H, Kohzai M, Sumita K, Tanigawa N.

  Predictive factors for pericardial effusion identified by heart dose-volume histogram analysis in oesophageal cancer patients treated with chemoradiotherapy.

  Br J Radiol　2015 Feb;88(1046):20140168.

• Chihiro Kondoh, Kohei Shitara, Motoo Nomura, Daisuke Takahari, Takashi Ura, Hiroyuki Tachibana, Natsuo Tomita, Takeshi Kodaira, Kei Muro

  Efficacy of palliative radiotherapy for gastric bleeding in patients with unresectable advanced gastric cancer: a retrospective cohort study

  BMC Palliat Care. 4（14）37, 2015

• Kyoko Murata, Shiro Hinotsu, Shota Hamada, Yasumasa Ezoe, Manabu Muto , Koji Kawakami

  The changing patterns of dispensing branded and generic drugs for the treatment of gastroesophageal reflux disease between 2006 and 2011 in Japan: a retrospective cohort study

  BMC Health Serv Res 2015 Feb:15:76

• Kazuhisa Yamaguchi, Hiroya Taniguchi, Azusa Komori, Yukiya Narita, Sohei Nitta, Motoo Nomura, Shigenori Kadowaki, Daisuke Takahari, Takashi Ura, Masashi Andoh, Kei Muro, Keita Mori and Yoshinori Igarashi

  A single -arm phase-II trial of combined chemotherapy with S-1, oral leucovorin, and bevacizumab in heavily pre-treated patients with metastatic colorectal cancer

  BMC Cancer　15:601, 2015

• Manabu Muto.

  Endoscopic disgnosis for superficial neoplasia at the head and neck regions.

  Eur J Cancer Prev. (in press)

2014年

• Takeshi Setoyama,Shinichi Miyamoto, Takahiro Horimatsu, Taro Funakoshi, Mitsuhiro Nikaido, Yuzo Kodama, Sachiko Minamiguchi, Tomoko Yamabata, Manabu Muto, Tsutomu Chiba.

  Bioactive insulin-like growth factors as a possible molecular target for non-islet cell tumor hypoglycemia.

  Cancer Biol Ther. 2014 Dec 2;15(12):1588-92.

• Nishikawa Y, Tsuji Y, Isoda H, Kodama Y, Chiba T.

  Perfusion in the tissue surrounding pancreatic cancer and the patient’s prognosis

  Biomed Res Int　2014：Article　ID　648021：2014.

• Yamada A, Cox MA, Gaffney KA, Moreland A, Boland CR, Goel A.

  Technical Factors Involved in the Measurement of Circulating MicroRNA Biomarkers for the Detection of Colorectal Neoplasia.

  PLoS One. 2014 Nov 18;9(11):e112481.

• Chikatoshi Katada, Manabu Muto, Satoshi Tanabe, Katsuhiko Higuchi, Tohru Sasaki, Mizutomo Azuma, Kenji Ishido, Natsuya Katada, Shinichi Sakuramoto, Keishi Yamashita, Takashi Masaki, Meijin Nakayama, Makito Okamoto, Wasaburo Koizumi.

  Factors associated with the presence of multiple Lugol-voiding lesions in patients with esophageal squamous-cell carcinoma.

  Dis Esophagus. 27(5):457-62,2014.

• Shinya Ohashi, Osamu Kikuchi, Mihoko Tsurumaki, Yukie Nakai, Daisuke Kuriyama, Hiroi Kasai, Takahiro Horimatsu, Shin’ichi Miyamoto, Akira Shimizu, Tsutomu Chiba, Manabu Muto.
  Preclinical validation of talaporfin sodium-mediated photodynamic therapy for esophageal squamous cell carcinoma.

  PLOS ONE 2014 Aug 4;9(8):e103126.

• Yoshiyuki Yukawa, Shinya Ohashi, Yusuke Amanuma, Yukie Nakai, Mihoko Tsurumaki, Osamu Kikuchi, Shin’ichi Miyamoto, Tsunehiro Oyama, Toshihiro Kawamoto, Tsutomu Chiba, Tomonari Matsuda, Manabu Muto.

  Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion.

  Am J Cancer Res. 2014 May 26;4(3):279-84. eCollection 2014.

• Kagawa S, Natsuizaka M, Whelan KA, Facompre N, Naganuma S, Ohashi S, Kinugasa H, Egloff AM, Basu D, Gimotty PA, Klein-Szanto AJ, Bass AJ, Wong KK, Diehl JA, Rustgi AK, Nakagawa H.

  Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities

  Oncogene 34：2347-2359：2014.

• Kanai M

  Therapeutic application of curcumin for patients with pancreatic cancer

  World Journal of Gastroenterology 20(28):9384-9391:2014

• Watanabe N, Narimatsu H, Noh JY, Kunii Y, Mukasa K, Matsumoto M, Suzuki M, Sekiya K, Ohye H, Yoshihara A, Iwaku K, Kobayashi S, Kameyama K, Kobayashi K, Nishikawa Y, Kami M, Sugino K, Ito K

  Rituximab-including combined modality treatment for primary thyroid lymphoma: an effective regimen for elderly patients

  Thyroid. 24(6):994-999:2014.

• Yamada A, Minamiguchi S, Sakai Y, Horimatsu T, Muto M, Chiba T, Boland CR, Goel A

  Colorectal advanced neoplasms occur through dual carcinogenesis pathways in individuals with coexisting serrated polyps

  PLoS One　9(5):e98059：2014

• Peng Xue, Masashi Kanai, Yukiko Mori, Takafumi Nishimura, Norimitsu Uza, Yuzo Kodama, Yoshiya Kawaguchi, Kyoichi Takaori, Shigemi Matsumoto, Shinji Uemoto, Tsutomu Chiba.

  Comparative outcomes between initially unresectable and recurrent cases of advanced pancreatic cancer following palliative chemotherapy

  Pancreas 2014; 43(3):411-6

• Funakoshi T, Yasui H, Boku N, Fukutomi A, Yamazaki K, Machida N, Todaka A, Tsushima T, Hamauchi S, Yokota T, Onozawa Y, Komatsu H, Endo M

  Clinicopathological features and outcomes of gastric cancer patients with pulmonary lymphangitis carcinomatosa

  Jpn J Clin Oncol. 44(9):792-798:2014.

• Ikezawa K, Kanai M, Ajiki T, Tsukamoto T, Toyokawa H, Terajima H, Furuyama H, Nagano H, Ikai I, Kuroda N, Awane M, Ochiai T, Takemura S, Miyamoto A, Kume M, Ogawa M, Takeda Y, Taira K, Ioka T.

  Patients with recurrent biliary tract cancer have a better prognosis than those with unresectable disease: retrospective analysis of a multi-institutional experience with patients of advanced biliary tract cancer who received palliative chemotherapy

  J Hepatobiliary Pancreat Sci 21(2):98-104:2014

• Kou T, Kanai M, Ikezawa K, Ajiki T, Tsukamoto T, Toyokawa H, Yazumi S, Terajima H, Furuyama H, Nagano H, Ikai I, Kuroda N, Awane M, Ochiai T, Takemura S, Miyamoto A, Kume M, Ogawa M, Takeda Y, Taira T, Ioka T

  Comparative Outcomes of Elderly and Non-elderly Patients Receiving First-Line Palliative Chemotherapy for Advanced Biliary Tract Cancer

  J Gastroenterol Hepatol 29:403-408:2014

• Yamanaka K, Hatano E, Kanai M, Tanaka S, Yamamoto K, Narita M, Nagata H, Ishii T, Machimoto T, Taura K, Uemoto S.

  A single-center analysis of the survival benefits of adjuvant gemcitabine chemotherapy for biliary tract cancer

  J Clin Oncol 19(3):185-9, 2014.

• Ueda K, Hirahashi J, Seki G, Tanaka M, Kushida N, Takeshima Y, Nishikawa Y, Fujita T, Nangaku M

  Successful treatment of acute kidney injury in patients with idiopathic nephrotic syndrome using human atrial natriuretic peptide

  Intern Med 53(8):865-869:2014.

• Ueda K, Hirahashi J, Seki G, Tanaka M, Kushida N, Takeshima Y, Nishikawa Y, Fujita T, Nangaku M

  Successful treatment of acute kidney injury in patients with idiopathic nephrotic syndrome using human atrial natriuretic peptide

  Intern Med 53(8):865-869:2014.

• Shimizu T, Marusawa H, Matsumoto Y, Inuzuka T, Ikeda A, Fujii Y, Minamiguchi S, Miyamoto S, Kou T, Sakai Y, Crabtree JE, Chiba T.

  Accumulation of somatic mutations in TP53 in gastric epithelium with Helicobacter pylori infection

  Gastroenterology. 2014;147(2):407-17.

• Nikaido M, Miyamoto S, Iinuma S

  Systemic ulcerative lesions in a patient with ischemic heart disease

  Gastroenterology. 147: e7-8. 2014

• Nishikawa Y, Tsubokura M, Kato S, Saito Y

  Possible Anisakiasis Associated with Fishery Resumption

  Disaster Med Public Health Prep 8(2):117-118:2014

• Matsumoto T, Hasegawa S, Matsumoto S, Horimatsu T, Okoshi K, Yamada M, Kawada K, Sakai Y

  Overcoming the challenges of primary tumor management in patients with metastatic colorectal cancer unresectable for cure and an asymptomatic primary tumor

  Dis Colon Rectum　57(6):679-86:2014

• Xue P, Kanai M, Mori Y, Nishimura T, Uza N, Kodama Y, Kawaguchi Y, Takaori K, Matsumoto S, Uemoto S

  Neutrophil-to-lymphocyte ratio for predicting palliative chemotherapy outcomes in advanced pancreatic cancer patients

  Cancer Med　3(2):406-415:2014

• Toyoda M, Ajiki T, Fujiwara Y, Nagano H, Kobayashi S, Sakai D, Hatano E, Kanai M, Nakamori S, Miyamoto A, Tsuji A, Kaihara S, Ikoma H, Takemura S, Toyokawa H, Terajima H, Morita S, Ioka T.

  Phase I study of adjuvant chemotherapy with gemcitabine plus cisplatin in patients with biliary tract cancer undergoing curative resection without major hepatectomy (KHBO10004）

  Cancer Chemother Pharmacol. 2014 Jun;73(6):1295-1301.

• Narita Y, Taniguchi H, Komori A, Nitta S, Yamaguchi K, Kondo C, Nomura M, Kadowaki S, Takahari D, Ura T, Andoh M, Muro K.

  CA19-9 level as a prognostic and predictive factor of bevacizumab efficacy in metastatic colorectal cancer patients undergoing oxaliplatin-based chemotherapy.

  Cancer Chemother Pharmacol. 　2014 Feb;73(2):409-16.

• Kobayashi S, Nagano H, Sakai D, Eguchi H, Hatano E, Kanai M, Seo S, Taura K, Fujiwara Y, Ajiki T, Takemurra S, Kubo S, Yanagimoto H, Toyokawa H, Tsuji A, Terajima H, Morita S, Ioka T.

  Phase I study of adjuvant gemcitabine or S-1 in patients with biliary tract cancers undergoing major hepatectomy

  Cancer Chemother Pharmacol 74:(4):669-709:2014.

• Yoko Mashimo, Yasumasa Ezoe, Kosuke Ueda, Yoshinao Ozaki, Yusuke Amanuma, Ikuo Aoyama, Takahiro Horimatsu, Shuko Morita, Shinichi Miyamoto, Tomonori Yano, Koji Higashino, Tsutomu Chiba, Manabu Muto.

  Salvage photodynamic therapy is an effective and safe treatment for patients with local failure after definitive chemoradiotherapy for esophageal squamous cell carcinoma.

  Journal of Cancer Therapy (JCT) 5(7):647-656.2014.

• Takeshi Setoyama, Shinichi Miyamoto, Takahiro Horimatsu, Shuko Morita, Yasumasa Ezoe, Manabu Muto, Go Watanabe, Eiji Tanaka, Tsutomu Chiba.

  Multimodal endoscopic treatment for delayed severe esophageal stricturecaused by incomplete stent removal.

  Dis Esophagus. 27(2):112-115.2014.

• Shinya Yamada, Hisashi Doyama, Kenshi Yao, Noriya Uedo, Yasumasa Ezoe, Ichiro Oda, Kazuhiro Kaneko,Yoshiro Kawahara, Cshizu Yokoi, Yasushi Sugiura, Hideki Ishikawa, Yoji Takeuchi, Yutaka Saito, Manabu Muto.

  An efficient diagnostic strategy for small, depressed early gastric cancer with magnifying narrow-band imaging: a post-hoc analysis of a prospective randomized controlled trial.

  Gastrointest Endosc. 2014 Jan;79(1):55-63.

2013年

• Nagai H, Kitano T, Nishimura T, Yasuda H, Nakata K, Takashima S, Kanai M, Matsumoto S, Mori Y, Kakudo Y, Sato H, Yamaguchi T, Kameno K, Kim YH, Mishima M, Yanagihara K.

  Use of glucose solution for the alleviation of gemcitabine-induced vascular pain: a double-blind randomized crossover study

  Support Care Cancer 21(12):3271-3278:2013.

• Watanabe T, Tsuji Y, Takahashi N, Yoshida T, Tamaoki M, Kikuchi O, Watanabe Y, Kodama Y, Isoda H, Yamamoto H, Chiba T

  Relationship Between Pancreatic Perfusion Parameters and Clinical Complications of Severe Acute Pancreatitis

  Pancreas. 42(1):180-182, 2013

• Takahashi Y, Nishikawa Y, Mori J, Hamaki T, Tanimoto T.

  Therapeutic platelet transfusion for hypoproliferative thrombocytopenia

  Lancet.　381(9868):724. 2013

• Nishikawa Y, Tanimoto T, Tsubokura M, Kami M, Saito Y

  Treatment for patients with indolent and mantle cell lymphoma

  Lancet 382(9896):1093-4, 2013

• Goto Y, Kodaira T, Fuwa N, Mizoguchi N, Nakahara R, Nomura M, Tomita N, Tachibana H.

  Alternating chemoradiotherapy in patients with nasopharyngeal cancer: prognostic factors and proposal for individualization of therapy.

  J Radiat Res　2013 Jan;54(1):98-107.

• Nomura M, Inoue K, Matsushita S, Takahari D, Kondoh C, Shitara K, Ura T, Hayashi K, Kojima H, Kamata M, Tatematsu M, Hosoda R, Sawada S, Oka H, Muro K.

  Serum Concentration of Fentanyl During Conversion from Intravenous to Transdermal Administration to Patients with Chronic Cancer Pain

  Clin J Pain　2013 Jun;29(6):487-91.

• Kanai M, Otsuka Y, Otsuka K, Sato M, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S, Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H.

  A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients.

  Cancer Chemother Pharmacol. 71(6):1521-30,2013.

• Nomura M, Kamata M, Kojima H, Hayashi K, Sawada S.

  Irsogladine maleate reduces the incidence of fluorouracil-based chemotherapy-induced oral mucositis.

  Ann Oncol.　2013 Apr;24(4):1062-6.

• Nishikawa Y, Okuda S, Takebayashi C, Tanimoto T, Kami M, Kobayashi K.

  A case of late onset erythropoietic protoporphyria associated with myelodysplastic syndrome treated by the combination of beta carotene and azacitidine

  Ann Hematol. 92(10):1415-6, 2013

• Tatematsu N, Ezoe Y, Tanaka E, Muto M, Sakai Y, Tsuboyama T.

  Impact of neoadjuvant chemotherapy on physical fitness, physical activity, and health-related quality of life of patients with resectable esophageal cancer

  Am J Clin Oncol. 36(1):53-6, 2013.

• Osamu Kikuchi, Yasumasa Ezoe, Shuko Morita, Takahiro Horimatsu, Manabu Muto.

  Narrow-band Imaging for the Head and Neck Region and the Upper Gastrointestinal Tract.

  Jpn J Clin Oncol 2013 May;43(5):458-65.

• Manabu Muto.

  Endoscopic diagnositic strategy of superficial esophageal squamous cell carcinoma.

  Dig Endosc. 2013 Mar;25 Suppl 1:1-6.

• Kohei Takizawa, Atsuo Takashima, Aya Kimura, Junki Mizusawa, Noriaki Hasuike, Hiroyuki Ono, Masanori Terashima, Manabu Muto, Narikazu Boku, Mitsuru Sasako and Haruhiko Fukuda for the Gastrointestinal Endoscopy Study Group (GIESG) and Stomach Cancer Study Group (SCSG) of the Japan Clinical Oncology Group (JCOG) .

  A Phase II Clinical Trial of Endoscopic Submucosal Dissection for Early Gastric Cancer of Undifferentiated Type: Japan Clinical Oncology Group Study JCOG1009/1010.

  Jpn J Clin Oncol. 2013 Jan;43(1):87-91.

• Chikatoshi Katada, Manabu Muto, Satoshi Tanabe, Katsuhiko Higuchi, Tohru Sasaki, Mizutomo Azuma, Kenji Ishido, Takashi Masaki, Meijin Nakayama, Makito Okamoto, Wasaburo Koizumi.

  Surveillance after endoscopic mucosal resection or endoscopic submucosal dissection for esophageal squamous cell carcinoma.

  Digestive Endosc. 2013 Mar;25 Suppl 1:39-43.

2012年

• Ishii N, Setoyama T, Deshpande GA, Omata F, Matsuda M, Suzuki S, Uemura M, Iizuka Y, Fukuda K, Suzuki K, Fujita Y.

  Endoscopic band ligation for colonic diverticular hemorrhage.

  Gastrointest Endosc 2012; 75: 382-7.

• Masayuki Watanabe, Hideo Baba, Chikashi Ishioka, Yasumasa Nishimura, Manabu Muto.

  Recent advances in diagnosis and treatment for malignancies of the gastrointestinal tract.

  Digestion. 85(2):95-98,2012

• Masaki T, Katada C, Nakayama M, Takeda M, Miyamoto S, Seino Y, Matsuba H, Okamoto T, Koizumi W, Tanabe S, Horiguchi S, Okamoto M, Muto M.

  Usefulness and pitfall of Narrow band imaging combined with magnifying endoscopy for detecting an unknown head and neck primary site with cervical lymph node metastasis.

  Auris Nasus Larynx. 2012 Oct;39(5):502-6.

• Saraya T, Ikematsu H, Fu KI, Tsunoda C, Yoda Y, Oono Y, Kojima T, Yano T, Horimatsu T, Sano Y, Kaneko K.

  Evaluation of complications related to therapeutic colonoscopy using the bipolar snare

  Surg Endosc. 26(2):533-40, 2012.

• Kanai M, Guha S, Aggarwal BB.

  The potential role og curcumin for treatment of pancreatic cancer

  Pancreatic Cancer molecular mechanism and target. In Tech Books 2012 Chapter 12:213-224, 2012.

• Ikematsu H1, Saito Y, Tanaka S, Uraoka T, Sano Y, Horimatsu T, Matsuda T, Oka S, Higashi R, Ishikawa H, Kaneko K.

  The impact of narrow band imaging for colon polyp detection: a multicenter randomized controlled trial by tandem colonoscopy.

  J Gastroenterol 47(10):1099-1107, 2012.

• Kikuchi O , Mouri H , Matsueda K and Yamamoto H.

  Endoscopic submucosal dissection for treatment of patients gged 75 years and over with esophageal cancer.

  ISRN Gastroenterol 2012:671324, 2012.

• Ohara Y, Kikuchi O, Goto T, Yoshida T, Mori H, Matsueda K, Yamamoto H.

  Successful treatment of a patient with sepsis and liver abscess caused by Edwardsiella tarda.

  Intern Med. 51:2813-2817, 2012.

• Nomura M, Shitara K, Kodaira T, Hatooka S, Mizota A, Kondoh C, Yokota T, Takahari D, Ura T, Muro K.

  Prognostic Impact of the 6th and 7th American Joint Committee on Cancer TNM Staging Systems on Esophageal Cancer Patients Treated with Chemoradiotherapy.

  Int J Radiat Oncol Biol Phys.　2012;82:946-952.

• Nomura M, Shitara K, Kodaira T, Kondoh C, Takahari D, Ura T, Kojima H, Kamata M, Muro K, Sawada S.

  Recursive Partitioning Analysis for New Classification of Patients with Esophageal Cancer Treated by Chemoradiotherapy.

  Int J Radiat Oncol Biol Phys. 　2012 Nov 1;84(3):786-92.

• Nagai H, Yasuda H, Hatachi Y, Xue D, Sasaki T, Yamaya M, Sakamori Y, Togashi Y, Masago K, Ito I, Kim YH, Mio T, Mishima M

  Nitric oxide (NO) enhances pemetrexed cytotoxicity via NO-cGMP signaling in lung adenocarcinoma cells in vitro and in vivo

  Int J Oncol 41(1):24-30, 2012.

• Nomura M, Kamata M, Kojima H, Sawada S

  Renal salt-wasting syndrome associated with docetaxel in an esophageal cancer patient

  Int Canc Conf J 　2012 1:67–69

• Tsuji Y, Watanabe T, Kudo M, Arai H, Strober W, Chiba T.

  Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis

  Immunity.37(2):326-38, 2012.

• Kondoh C, Takahari D, Shitara K, Mizota A, Nomura M, Yokota T, Ura T, Ito S, Kawai H, Sawaki A, Muro K.

  Efficacy of docetaxel in patients with paclitaxel-resistant advanced gastric cancer.

  Gan To Kagaku Ryoho　2012 Oct;39(10):1511-5.

• Natsuizaka M, Naganuma S, Kagawa S, Ohashi S, Ahmadi A, Subramanian H, Chang S, Nakagawa KJ, Ji X, Liebhaber SA, Klein-Szanto AJ, Nakagawa H

  Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis

  FASEB J 26(6):2620-30:2012.

• Koyasu S, Isoda H, Tsuji Y, Yamamoto H, Matsueda K, Watanabe Y, Chiba T, Togashi K.

  Hepatic arterial perfusion increases in the early stage of severe acute pancreatitis patients: Evaluation by perfusion computed tomography

  Eur J Radiol. 81(1):43-6, 2012.

• Yokoyama A, Ichimasa K, Ishiguro T, Mori Y, Ikeda H, Hayashi T, Minami H, Hyashi S, Watanabe G, Inoue H, Kudo SE

  Is it proper to use non-magnified narrow-band imaging for esophageal neoplasia screening? Japanese single-center, prospective study.

  Dig Endosc 24:412-8, 2012

• Goto O, Fujishiro M, Oda I, Kakushima N, Yamamoto Y, Tsuji Y, Ohata K, Fujiwara T, Fujiwara J, Ishii N, Yokoi C, Miyamoto S, Itoh T, Morishita S, Gotoda T, Koike K.

  A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding.

  Dig Dis Sci. 57(2):435-9, 2012.

• Setoyama T, Miyamoto S, Fukuda K.

  Hemosuccus pancreaticus diagnosed with concurrent endoscopic retrograde pancreatography and selective angiography

  Clin Gastroenterol Hepatol. 10(4): A28, 2012.

• Kanai M, Hatano E, Kobayashi S, Fujiwara Y, Sakai D, Kodama Y, Ajiki T, Nagano H, Ioka T

  Phase I trial of oral S-1 combined with gemcitabine and cisplatin for advanced biliary tract cancer

  Chemother Pharmacol. 　69(5):1181-8, 2012.

• Kanai M, Imaizumi A, Otsuka Y, Sasaki H, Hashiguchi M, Tsujiko K, Matsumoto S, Ishiguro H, Chiba T.

  Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers.

  Cancer Chemother Pharmacol. 69(1):65-70:2012.

• Nomura M, Kodaira T, Furutani K, Tachibana H, Tomita N, Goto Y.

  Predictive factors for radiation pneumonitis in oesophageal cancer patients treated with chemoradiotherapy without prophylactic nodal irradiation.

  Br J Radiol. 　2012 Jun;85(1014):813-8.

• Shimatsu A, Kakeya H, Imaizumi A, Morimoto T, Kanai M, Maeda S

  Clinical application of “Curcumin”, a multi-functional substance

  Anti-Aging Medicine. 9(1):43-51, 2012.

• Nishikawa Y, Hoshina K, Sasaki H, Hosaka A, Yamamoto K, Okamoto H, Shigematsu K, Miyata T.

  Acute remodeling of an adjoining aneurysm after endovascular treatment of a ruptured splanchnic arterial aneurysm: a case of clinically diagnosed segmental arterial mediolysis.

  Ann Vasc Dis. 5(4):449-53, 2012.

• Naganuma S, Whelan KA, Natsuizaka M, Kagawa S, Kinugasa H, Chang S, Subramanian H, Rhoades B, Ohashi S, Itoh H, Herlyn M, Diehl JA, Gimotty PA, Klein-Szanto AJ, Nakagawa H.

  Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma.

  Am J Cancer Res 2(4):459-75, 2012.

• Yoshiyuki Yukawa, Manabu Muto, Yusuke Amanuma, Yasumasa Ezoe,Yoko Mashimo, Kimiko Hori, Takahiro Horimatsu, Shuko Morita, Shinichi Miyamoto,Sashiko Minamiguchi, Tsutomu Chiba.

  Elimination of esophageal multiple precancerous lesions by chemotherapy: potential chemoprevention of metachronous multiple cancer development after curative treatment.

  Esophagus. 9(4):203-209.2012

• Chikatoshi Katada, Manabu Muto, Meijin Nakayama, Satoshi Tanabe, Katsuhiko Higuchi, Tohru Sasaki, Mizutomo Azuma, Kenji Ishido,Natsuya Katada, Keishi Yamashita, Masayuki Nemoto, Tomotaka Shibata, Takashi Masaki, Makito Okamoto, Wasaburo Koizumi.

  Risk of superficial squamous cell carcinoma developing in the head and neck region in patients with esophageal squamous cell carcinoma.

  Laryngoscope. 2012 Jun;122(6):1291-6.

• Shinichi Miyamoto, Yoko Mashimo, Takahiro Horimatsu, Yasumasa Ezoe, Shuko Morita, Manabu Muto, Tsutomu Chiba.

  Cerebral air embolism caused by chemoradiotherapy for esophageal cancer.

  J Clin Oncol. 2012 Sep 1;30(25):e237-8.

• Yoshiyuki Yukawa, Manabu Muto, Kimiko Hori, Haruna Nagayoshi, Akira Yokoyama, Tsutomu Chiba, Tomonari Matsuda.

  Combination of ADH1B*2/ALDH2*2 polymorphisms alters acetaldehyde-derived DNA damage in the blood of Japanese alcoholics.

  Cancer Sci. 2012 Sep;103(9):1651-5.

• Takahiro Horimatsu, Shinichi Miyamoto, Yasumasa Ezoe, Manabu Muto, Akihiko Yoshizawa, Yoshiharu Sakai.

  Gastrointestinal: Case of early-stage squamous cell carcinoma of the anal canal diagnosed using narrow-band imaging system with magnification.

  J Gastroenterol Hepatol. 27(8):1406. 2012

• Takahiro Horimatsu, Manabu Muto, Yusuke Yoda, Tomonori Yano, Yasumasa Ezoe, Shinichi Miyamoto, Tsutomu Chiba.

  Tissue damage in the canine normal esophagus by photoactivation with taraporfin sodium (Laserphyrin): A preclinical study.

  PLOS ONE. 2012;7(6):e38308.

• Tomonori Yano, Manabu Muto, Kenichi Yoshimura, Miyuki Niimi, Yasumasa Ezoe, Yusuke Yoda, Yoshinobu Yamamoto, Hogara Nishisaki, Koji HIgashino and Hiroyasu Iishi.

  Phase I study of photodynamic therapy using talaporfin sodium and diode laser for local failure after chemoradiotherapy for esophageal cancer.

  Radiat Oncol. 2012 Jul 23;7:113.

• Kimiko Hori, Shin’ichi Miyamoto, Yoshiyuki Yukawa, Manabu Muto, Tsutomu Chiba, Tomonari Matsuda.

  Stability of acetaldehyde-derived DNA adduct in vitro.

  Biochem a Biophys Res Commun. 423(4):642-646. 2012

• Miyamoto S, Morita S, Muto M.

  Multiple early-stage malignant melanoma of the esophagus with a long follow-up period after endoscopic treatment: report of a case and a literature review

  Esophageal Cancer -Cell and Molecular Biology, Biomarkers, Nutrition and Treatment　Croatia:

  INTECH 2012;227-238

• Tsubasa Watanabe, Shinichi Miyamoto, Koji Kitagori, Takahiro Horimatsu, Shuko Morita, Yoko Mashimo, Yasumasa Ezoe, Manabu Muto, Tsutomu Chiba.

  A case of long-term survival of metastatic small round cell tumor treated with multimodal therapy.

  Oncol Let. 3(1):30-34.2012

• Tsunehiro Oyama, Hidetaka Uramoto, Norio Kagawa, Takashi Yoshimatsu, Toshihiro Osaki, Ryoichi Nakanishi, Hisao Nagaya, Kazuhiro Kaneko, Manabu Muto, Toshihiro Kawamoto, Fumihiro Tanaka, Akinobu Gotoh.

  Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism.

  Front Biosci S4,1539-1546.2012

• Tomonori Yano, Manabu Muto, Keiko Minashi, Junko Iwasaki, Takashi Kojima, Nozomu Fuse, Toshihiko Doi, Kazuhiro Kaneko, Atsushi Ohtsu.

  Photodynamic therapy as salvage treatment for local failure after chemoradiotherapy in patients with esophageal squamous cell carcinoma: a phase II study.

  Int J Cancer. 131(5):1228-1234. 2012

• Manabu Muto, Yasumasa Ezoe, Tomonori Yano, Ikuo Aoyama, Yusuke Yoda, Keiko Minashi, Shuko Morita, Takahiro Horimatsu, Shin-ichi Miyamoto, Atsushi Ohtsu, Tsutomu Chiba.

  Usefulness of endoscopic radial incision and cutting method for refractory esophagogastric anastomotic stricture

  Gastrointest Endosc 75:965-72, 2012

2011年

• Ohashi S, Natsuizaka M, Naganuma S, Kagawa S, Kimura S, Itoh H, Kalman RA, Nakagawa M, DarlingDS, Basu D, Gimotty PA, Klein-Szanto AJ,Diehl AJ, Herlyn M, and Nakagawa H:

  A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT competent cells that express the ZEB transcription factors.

  Cancer Res 2011 Sep ;71(21):6836-47.

• Ohashi S, Natsuizaka M, Nakagawa H:

  MMP7 and activation of IGF-1R: A new insight into anti-EGFR therapeutic resistance in metastatic colorectal cancer.

  Cancer Biology & Therapy. 2011 Jan 15; 11(2), 184-187

• Akitake R, Miyamoto S, Nakamura F, Horimatsu T, Ezoe Y, Muto M, Chiba T.

  Early Detection of 5-FU-Induced Acute Leukoencephalopathy on Diffusion-Weighted MRI.

  Jpn J Clin Oncol.2011 Jan;41(1):121-4

• Tu CH, Muto M, Horimatsu T,Taku K, Yano T, Minashi K, Onozawa M, Nihei K, Ishikura S, Ohtsu A, Yoshida S.

  Submucosal tumor appearance is a useful endoscopic predictor of early primary-site recurrence after definitive chemoradiotherapy for esophageal squamous cell carcinoma.

  Dis Esophagus.2011 May;24(4):274-8

• Mashimo Y, Horimatsu T, Miyamoto S.

  Umbilical Metastasis (Sister Mary Joseph’s Nodule) From Esophageal Squamous Cell Carcinoma.

  Clin Gastroenterol Hepatol. 2011 Aug;9(8):A20

• Yuki Asada, Manabu Muto, Tomonori Yano, Keiko Minashi, Satoshi Fujii,Atsushi Ochiai, Atsushi Ohtsu, Shigeaki Yoshida.

  Successful Endosocpic Submucosal Dissection for Esophageal Squamous Cell Carcinoma together with a Lipoma.

  Hepato-Gastroenterology. 58(110-111):1595-1597.2011

• Nomura M, Kamata M, Kojima H, Hayashi K, Kozai M, Sawada S.

  Six- versus 12-h conversion method from intravenous to transdermal fentanyl in chronic cancer pain: a randomized study.

  Support Care Cancer.　2011 May;19(5):691-5. Epub 2010 Jun 13.

• Kobayashi N, Ueki K, Okazaki Y, Iwane A, Kubota N, Ohsugi M, Awazawa M, Kobayashi M, Sasako T, Kaneko K, Suzuki M, Nishikawa Y, Hara K, Yoshimura K, Koshima I, Goyama S, Murakami K, Sasaki J, Nagai R, Kurokawa M, Sasaki T, Kadowaki T.

  Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance

  Proc Natl Acad Sci USA. 2011:108(14):5753-8.

• Hirota M, Tsuda M, Tsuji Y, Kanno A, Kikuta K, Kume K, Hamada S, Unno J, Ito H, Ariga H, Chiba T, Masamune A, Satoh K, Shimosegawa T

  Perfusion Computed Tomography Findings of Autoimmune Pancreatitis.

  Pancreas. 40(8):1295-301, 2011.

• Mizota A, Shitara K, Kondo C, Nomura M, Yokota T, Takahari D, Ura T, Muro K.

  A Retrospective Comparison of Docetaxel and Paclitaxel for Patients with Advanced or Recurrent Esophageal Cancer Who Previously Received Platinum-Based Chemotherapy.

  Oncology　2011 Nov 17;81(3-4):237-242.

• Inoue K, Matsushita S, Nomura M, et al.

  Determination of fentanyl drug in cancer patient serum by liquid chromatography with mass spectrometry.

  Jpn J Pharm Palliat Care Sci 　2011;4:111-116.

• Shitara K, Mizota A, Yatabe Y, Kondo C, Nomura M, Yokota T, Takahari D, Ura T, Muro K.

  Lapatinib Plus Trastuzumab for a Patient with Heavily Pre-treated Gastric Cancer that Progressed after Trastuzumab.

  Jpn J Clin Oncol.　2011 May;41(5):663-5.

• Zaima C, Kanai M, Ishikawa S, Kawaguchi Y, Masui T, Mori Y, Nishimura T, Matsumoto S, Yanagihara K, Chiba T, Mimori T

  A case of progressive digital ischemia after early withdrawal of gemcitabine and S-1 in a patient with systemic sclerosis

  Jpn J Clin Oncol. 2011 Jun;41(6):803-6.

• Shitara K, Oze I, Mizota A, Kondo C, Nomura M, Yokota T, Takahari D, Ura T, Yuki S, Komatsu Y, Matsuo K, Muro K.

  Randomized Phase II Study Comparing Dose Escalated Weekly Paclitaxel vs. Standard Dose Weekly Paclitaxel for Patients with Previously Treated Advanced Gastric Cancer.

  Jpn J Clin Oncol　2011 Feb;41(2):287-90.

• Ueda K, Muto M, Chiba T.

  Unusual esophageal ulcer caused by Alendronate Sodium

  Gastrointest Endosc. 73(5):1037-8:2011

• Nakanishi Y, Miyamoto S, Ishizu S, Seno H, Muto M, Chiba T,

  An unusual cause of dysphagia after endoscopic resection of an early esophageal cancer.

  Endoscopy .43 Suppl 2 UCTN:E156-7. 2011

• Yano T, Muto M, Minashi K, Kaneko K, Onozawa M, Nihei K, S Ishikura, A Ohtsu.

  Long-term results of salvage photodynamic therapy for patients with local failure after chemoradiotherapy for esophageal squamous cell carcinoma.

  Endoscopy. 43(8):657-63:2011

• Mizota A, Shitara K, Kondo C, Nomura M, Yokota T, Takahari D, Ura T, Muro K.

  A case of heavily pretreated rectal cancer with disseminated intravascular coagulation that improved following reintroduction of FOLFOX plus bevacizumab.

  Int J Clin Oncol　2011;16:766-769.

• Nagai H, Tanaka S, Niimi M, Seo N, Sasaki T, Date H, Mishima M, Yasuda H, Yanagihara K.

  Safety of erlotinib treatment in outpatients with previously treated non-small-cell lung cancer in Japan

  Int J Clin Oncol 2011:16(5):560-567.

• Mizota A, Shitara K, Kondo C, Nomura M, Yokota T, Takahari D, Ura T, Inaba Y, Yamaura H, Sato Y, Kato M, Muro K.

  Retrospective analysis of cetuximab monotherapy for patients with irinotecan-intolerant metastatic colorectal cancer.

  Int J Clin Oncol　2011 Aug;16(4):416-20.

• Shitara K, Matsuo K, Mizota A, Kondo C, Nomura M, Takahari D, Yokota T, Ura T, Ito S, Sawaki A, Tajika M, Kawai H, Muro K.

  Association of fluoropyrimidines, platinum agents, taxanes, and irinotecan in any line of chemotherapy with survival in patients with advanced gastric cancer.

  Gastric Cancer.　2011 Jun;14(2):155-60. Epub 2011 Feb 23.

• Mizota A, Shitara K, Kondo C, Nomura M, Yokota T, Takahari D, Ura T, Muro K.

  FOLFOX plus cetuximab for a patient with metastatic colorectal cancer with icterus due to multiple liver metastases.

  Gan To Kagaku Ryoho. 　2011 Jul;38(7):1205-8.

• Kishimoto M, Tsuji Y, Katabami N, Shimizu J, Lee KJ, Iwasaki T, Miyake YI, Yazumi S, Chiba T, Yamada K.

  Measurement of canine pancreatic perfusion using dynamic computed tomography: influence of input-output vessels on deconvolution and maximum slope methods

  Eur J Radiol 77(1):175-81, 2011.

• Alaboudy AA, Elbahrawy A, Matsumoto S, Yoshizawa A.

  Conventional narrow-band imaging has good correlation with histopathological severity of Helicobacter pylori gastritis

  Dig Dis Sci 54(4):1127-1130, 2011.

• Kanai M, Yoshimura K, Tsumura T, Asada M, Suzuki C, Niimi M, Matsumoto S, Nishimura T, Nitta T, Yasuchika K, Taura K, Mori Y, Hamada A, Inoue N, Tada S, Yanagihara K, Yazumi S, Osaki Y, Chiba T, Ikai I, Fukushima M, Uemoto S, Hatano E.

  A multi-institution phase II study of gemcitabine/S-1 combination chemotherapy for patients with advanced biliary tract cancer

  Cancer Chemother Pharmacol. 67(6):1429-34, 2011.

• Shitara K, Matsuo K, Oze I, Mizota A, Kondo C, Nomura M, Yokota T, Takahari D, Ura T, Muro K.

  Meta-analysis of neutropenia or leukopenia as a prognostic factor in patients with malignant disease undergoing chemotherapy.

  Cancer Chemother Pharmacol.　2011 Aug;68(2):301-7. Epub 2010 Oct 20. Review.

• Kanai M, Ishiguro H, Mori Y, Kitano T, Nishimura T, Matsumoto S, Yanagihara K, Chiba T, Toi M.

  Temporary blood pressure drop after bevacizumab administration is associated with clinical course of advanced colorectal cancer

  Br J Cancer. 105(11):1693-6, 2011.

• Yokota T, Hatooka S, Ura T, Abe T, Takahari D, Shitara K, Nomura M, Kondo C, Mizota A, Yatabe Y, Shinoda M, Muro K.

  Docetaxel plus 5-Fluorouracil and Cisplatin (DCF) Induction Chemotherapy for Locally Advanced Borderline-resectable T4 Esophageal Cancer.

  Anticancer Res.　2011 Oct;31(10):3535-41.

• Watanabe T, Tsuji Y, Kodama Y, Isoda H, Yamamoto H, Chiba T.

  Relationship between serum angiopoietin-2 level and perfusion CT parameters in severe acute pancreatitis

  Am J Gastroenterol. 106(10):1859-61.

• Aoyagi K, Minashi K, H Igaki, Tachimori Y, Nisimura T, Hokamura N, Ashida A, Daiko H, Ochiai A, Muto M, Ohtsu A, Yoshida T, H Sasaki.

  Artificially induced epithelail mesenchymal transition in surgical subjects: its implications in clinical and basic cancer research.

  PLOS ONE. 21;6(4):2011

• Matsuba H, Katada C, Masaki T, Nakayama M, Okamoto T, Hanaoka N, Tanabe S, Koizumi Wasaburo, Okamoto M, Muto M.

  Diagnosis of the extent of advanced oropharyngeal and hypopharyngeal cancers by narrow band imaging with magnifying endoscopy.

  The Laryngoscope.121(4):753-9:2011

• Muto M, Morita S, Ezoe Y, Horimatsu T, Miyamoto S, Yoshii T, Iizuka T, Chiba T.

  Macroscopic Estimation of Submucosal Invasion in the Esophagus.

  Tec Gastrointest Endosc. 13(1);8-13: 2011

• Matsubara J, Honda K, Ono M, Tanaka Y, Kobayashi M, Jung G, Yanagisawa K, Sakuma T, Nakamori S, Sata N, Nagai H, Ioka T, Okusaka T, Kosuge T, Tsuchida A, Shimahara M, Yasunami Y, Chiba T, Hirohashi S, Yamada T.

  Reduced plasma level of CXC chemokine ligand 7 in patients with pancreatic cancer.

  Cancer Epidemiol Biomarkers Prev. 2011; 20: 160-71.

• Matsubara J, Shimada Y, Kato K, Nagai Y, Iwasa S, Nakajima TE, Hamaguchi T, Yamada Y, Takagi S, Kobayashi K, Yoshioka A, Nakayama N,Tsuji A:

  Phase II study of bolus 5-fluorouracil and leucovorin combined with weekly paclitaxel (FLTAX) as first-line therapy for advanced gastric cancer.

  Oncology 2011; 81: 291-297

• Matsubara J, Honda K, Ono M, Sekine S, Tanaka Y, Kobayashi M, Jung G, Sakuma T, Nakamori S, Sata N, Nagai H, Ioka T, Okusaka T, Kosuge T,Tsuchida A, Shimahara M, Yasunami Y, Chiba T, Yamada T:

  Identification of adipophilin as a potential plasma biomarker for colorectal cancer using label-free quantitative mass spectrometry and protein microarray.

  Cancer Epidemiol Biomarkers Prev 2011; 20: 2195-2203.

• Ezoe Y, Muto M, Uedo N, Doyama H, Yao K, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, Ishikawa H, Takeuchi Y, Kaneko Y, Saito Y

  Magnifying Narrowband Imaging Is More Accurate than Conventional White-Light Imaging in Diagnosis of Gastric Mucosal Cancer

  Gastroenterology 141(6);2017-2025:2011

• Muto M, Satake H, Yano T, Minashi K, Hayashi R, Fujii S, Ochiai A, Ohtsu A, Morita S, Horimatsu T, Ezoe Y, Miyamoto S, Asato R, Tateya I, Yoshizawa A, Chiba T

  Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer

  Gastrointest Endosc 74(3);477-484:2011

• Muto M, Higuchi H, Ezoe Y, Horimatsu T, Morita S, Miyamoto S, Chiba T

  Differences of image enhancement in image-enhanced endoscopy: narrow band imaging versus flexible spectral imaging color enhancement

  J Gastroenterol 46(8);998-1002:2011

• Horimatsu T, Miyamoto S, Morita S, Mashimo Y, Ezoe Y, Muto M, Chiba T

  Pharmacokinetics of oxaliplatin in a hemodialytic patient treated with modified FOLFOX-6 plus bevacizumab therapy

  Cancer Chemother Pharmacol 68(1);263-266:2011

• Ezoe Y, Fujii S, Muto M, Ochiai A, Ohtsu A

  Epidermoid metaplasia of the esophagus: endoscopic features and differential diagnosis

  Hepatogastroenterol 58(107-108);809-813:2011

• Miyamoto S, Konda Y, Matsui M, Sawada K, Ikeda K, Watanabe N, Kawanami C, Chiba T.

  Acute airway obstruction in a patient with achalasia.

  Intern Med. 2011;50(20):2333-6.

• Ezoe Y, Muto M, Horimatsu T, Morita S, Miyamoto S, Mochizuki S, Minashi K, Yano T, Ohtsu A, Chiba T.

  Efficacy of preventive endoscopic balloon dilation for esophageal stricture after endoscopic resection.

  J Clin Gastroenterol. 45;222-227:2011.

• Yamada A, Notohara K, Aoyama I, Miyoshi M, Miyamoto S, Fujii S, Yamamoto H.

  Endoscopic features of sessile serrated adenoma and other serrated colorectal polyps.

  Hepato-Gastroenterol. 2011; 58: 45-51.

• Yamada A, Fujii S, Daiko H, Nishimura M, Chiba T, Ochiai A.

  Aberrant expression of EZH2 is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the esophagus.

  Int J Oncol. 2011; 38(2): 345-353.

• Matsubara J:

  [review article] Biomarkers in molecularly targeted therapy for cancer.

  Recent Pat Biomarkers 2011; 1: 110-118.

• Saraya T, Ikematsu H, Fu KI, Tsunoda C, Yoda Y, Oono Y, Kojima T, Yano T, Horimatsu T,et al.
  Evaluation of complications related to therapeutic colonoscopy using the bipolar snare.

  Surg Endosc. 2011 Sep 23.

2010年

• Ohashi S, Natsuizaka M, Yashiro-Ohtani Y, Kalman RA, Nakagawa M, Wu L, Klein-Szanto AJ, Herlyn M, Diehl AJ, Katz JP, Pear WS, Seykora JT, and Nakagawa H:

  NOTCH1 and NOTCH3 cordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.

  Gastroenterology 2010 Dec; 139 (6): 2113-23.

• Ohashi S, Natsuizaka M, Wong GS, Michaylira CZ, Grugan KD, Stairs DB, Kalabis J, Vega ME, Kalman RA,

  Nakagawa M, Klein-Szanto AJ, Herlyn M, Diehl JA, Rustgi AK, Nakagawa H.

  Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcriptional factors.

  Cancer Res, 2010 May 15; 70(10): 4174-84.

• Muto M, Minashi K, Yano T, Saito Y, Oda I, Nonaka S, Omori T, Sugiura H, Goda K, Kaise M, Inoue H, Ishikawa H, Ochiai A, Shimoda T, Watanabe H, Tajiri H, Saito D.

  Early detection of superficial squamous cell carcinoma in the　head and nec region and esophagus by narrow band imaging: a multicenter　randomized controlled trial.

  J Clin Oncol, 28(9):1566-1572 2010

• Katada C, tanabe S, Koizumi W, Higuchi K, Sasaki T, Azuma M, Katada N, Masaki T, Nakayama M, Okamoto M, Muto M,

  Narrow band imaging for detecting superficial squamous cell carcinoma of the head neck in patients with esophageal squmaous cell carcinoma.

  Endoscopy, 42(3):185-90 2010

• Hayashi T, Muto M, Hayashi R, Ugumori T, Kishimoto S, Ebihara S.

  Usefulness of Narrow Band Imaging for detecting the primary tumor site in patients with primary unknown cervical lymph node metastasis.

  Jpn J Clin Oncol, 40 (6):537-541 2010

• Fujii S, Yamazaki M, Muto M, Ochiai A.

  Microvascular irregularities are associated　with composition of squamous epithelial lesion and correlate with　subepithelial invasion of superficial type pharyngeal squamous cell　carcinoma.

  Histopathology, 56(4):510-522 2010

• Ezoe Y, Muto M, Horimatsu T, Minashi K, Yano T, Chiba T, Ohtsu A.

  Magnifying narrow-band imaging versus magnifying white-light imaging for the differential diagnosis of gastric small depressive lesions: a prospective study.

  Gastrointest Endosc.2010 Mar;71(3) :477-84.

• Matsunaka T, Miyamoto S, Shitara K, Ochiai A, Chiba T.

  Ligand-specific antibodies to insulin-like growth factors suppress intestinal polyp formation in apc+/- mice.

  Mol Cancer Ther. 2010;9(2):419-28.

• Kitagori K, Miyamoto S, Sakurai T.

  Adenocarcinoma derived from Brunner’s gland.

  Clin Gastroenterol Hepatol 2010;8(4):A26

• Matsubara J, Ono M, Honda K, Negishi A, Ueno H, Okusaka T, Furuse J, Furuta K, Sugiyama E, Saito Y, Kaniwa N, Sawada J, Shoji A, Sakuma T, Chiba T, Saijo N, Hirohashi S, Yamada T:

  Survival prediction for pancreatic cancer patients receiving gemcitabine treatment.

  Mol Cell Proteomics 2010; 9: 695-704.

• Matsubara J, Hirashima Y and Yamada Y:

  Impact of HER2, EGFR, IGF-1R, and VEGFR expressions on the outcome of chemotherapy for advanced gastric cancer.

  Gan To Kagaku Ryoho 2010; 37: 1489-1496.

2009年

• Harima Y, Ikeda K, Utsunomiya K, Shiga T, Komemushi A, Kojima H, Nomura M, Kamata M, Sawada S.

  Identification of genes associated with progression and metastasis of advanced cervical cancers after radiotherapy by cDNA microarray analysis.

  Int J Radiat Oncol Biol Phys.　2009;75(4):1232-9.

• Muto M, Horimatsu T, Ezoe Y, Morita S, Miyamoto S.

  Improving visualization techniques by narrow band imaging and magnification endoscopy.

  J Gastroenterol Hepatol.2009 Aug;24(8):1333-46.

• Morita S, Miyamoto S, Matsumoto S, Muto M, Chiba T.

  Multiple early-stage malignant melanoma of the esophagus with long follow-up period after endoscopic treatment: report of a case.

  Esophagus 2009;6(4):249-252.

• Kurokawa Y, Muto M, Minashi K, Boku N, and Fukuda H, for the Gastrointestinal Oncology Study Group of Japan Clinical Oncology Group (JCOG).

  A phase II trial of combined treatment of endoscopic mucosal resection and chemoradiotherapy for clinical stage I esophageal carcinoma: Japan Clinical Oncology Group Study JCOG0508.

  Jpn J Clin Oncol. 39(10):686-9, 2009

• Onozawa M, Nihei K, Oshikura S, Minashi K, Yano T, Muto M, Ohtsu A, Ogino T.

  Elective nodal irradiation (ENI) in definitive chemoradiotherapy (CRT) for squamous cell carcinoma of the thoracic esophagus.

  Radiotherapy and Oncol.92(2):266-9, 2009

• Kaltenbach T, Muto M, Soetikno R, Dev P, Okamura K, Hahm J, Shimizu S.

  Teleteaching endoscopy: the feasibility of real-time, uncompressed video transmission by using advanced-network technologies.

  Gastrointest Endosco.70(5):1013-7, 2009

• Yokoyama A, Kumagai Y, Yokoyama T, Omori T, Kato H, Igaki H, Tsujinaka T, Muto M, Yokoyama M, Watanabe H.

  Health risk appraisal models for mass screening for esophageal and pharyngeal cancer: an endoscopic follow-up study of cancer-free Japanese men.

  Cancer Epidemiol Biomarkers Prev. 18(2):651-5, 2009

• Ugumori T, Muto M, Hayashi R, Hayashi T, Kishimoto S.

  Prospective study of early detection of pharyngeal superficial carcinoma with the narrowband imaging laryngoscope.

  Head Neck. 31(2):189-94, 2009

• Muto M, Horimatsu T, Ezoe Y, Hori K, Yukawa Y, Morita S, Miyamoto S, Chiba T.

  Narrow-band imaging of the gastrointestinal tract.

  J Gastroenterol. 2009;44(1):13-25.

• Fujiwara M, Miyamoto S, Iguchi K, Matsunaka T, Sakashita H, Tsuruyama T, Kanegane H, Marusawa H, Nakase H, Chiba1 T.

  Acute Epstein-Barr Virus infection presenting as severe gastroenteritis without infectious mononucleosis-like manifestations.

  Clin J Gastroenterol 2009;2:398-403.

• Akitake R, Nakase H, Ueno S, Miyamoto S, Iehara N, Chiba T.

  Involvement of Lupus Enteritis in a Patient with Lupus Cystitis and Nephritis.

  Digestion 2009;80:160-164.

• Horimatsu T, Sano Y, Kaneko K, Ikematsu H, Katagiri A, Yano T, Fu K, Muto M, Fujii S, Ochiai A, Yoshida S.

  Relationship between MVD and meshed-capillaries using magnifying NBI colonoscopy in colorectal precursor lesions.

  Hepatogastroenterology. 2009;56(90) :372-7.

• Horimatsu T, Yano T, Doi T, Fujii S, Kaneko K.

  Complete resection of alpha-fetoprotein-producing early gastric cancer by using endoscopic submucosal dissection.

  Gastrointest Endosc.2009 Mar;69(3) :565-6.

• Sano Y, Ikematsu H, Fu KI, Emura F, Katagiri A, Horimatsu T, Kaneko K, Soetikno R, Yoshida S.

  Meshed capillary vessels by use of narrow-band imaging for differential diagnosis of small colorectal polyps.

  Gastrointest Endosc. 2009;69(2):278-83.

• Matsubara J, Ono M, Negishi A, Ueno H, Okusaka T, Furuse J, Furuta K, Sugiyama E, Saito Y, Kaniwa N, Sawada J, Honda K, Sakuma T, Chiba T, Saijo N, Hirohashi S, Yamada T:

  Identification of a predictive biomarker for hematologic toxicities of gemcitabine.

  J Clin Oncol 2009; 27: 2261-2268.

• Matsubara J, Ono M and Yamada T:

  [review article] Predictive markers for chemotherapy toxicity: an important factor in personalized therapy.

  Eur J Clin Med Oncol 2009; 1: 1-6.

• Takai A, Setoyama T, Miyamoto S.

  Pancreatic Somatostatinoma With vonRecklinghausen’s Disease.

  Clin Gastroenterol Hepatol 2009;7(5):A28.

2008年

• Muto M.

  Endoscopic diagnosis and treatment of superficial cancer in the oropharynx and hypopharynx.

  In “New challenges in gastrointestinal endoscopy”, P67-76, ed. H. Tajiri and K Yasuda, Springer (Tokyo), 2008

• Yokoyama T, Yokoyama A, Kumagai Y, Omori T, Kato H, Igaki H, Tsujinaka T, Muto M, Yokoyama M, and Watanabe H.

  Health risk appraisal models for mass screening of esophageal cancer in japanese men.

  Cancer Epidem Biomark & Prev 17(10):2846-2854, 2008

• Komemushi A, Tanigawa N, Kariya S, Kojima H, Shomura Y, Tokuda T, Nomura M, Terada J, Kamata M, Sawada S

  Intraosseous Venography with Carbon Dioxide in Percutaneous Vertebroplasty: Carbon Dioxide Retention in Renal Veins.

  Cardiovasc Intervent Radiol　2008;31(6):1174-1177

• Yano T, Muto M, Hattori S, Minashi K, Onozawa M, Nihei K, Ishikura S, Ohtsu A, Yoshida S.

  Long-term results of salvage endoscopic mucosal resection in patients with local failure after definitive chemoradiotherapy for esophageal squamous cell carcinoma.

  Endoscopy 40(9):717-721, 2008

• Oyama T, Sugio K, Isse T, Matsumoto A, Nose N, Urammoto H, Nozoe T, Morita M, Kagawa N, Osaki T, Muto M, Yasumoto K, Kawamoto T.

  Expression of cytochrome P450 in non-small cell lung cancer.

  Frontiers in Bioscience 13,5787-5793, 2008

• Fuse N, Doi T, Ohtsu A, Yano T, Hamamoto Y, Minashi K, Tahara M, Muto M, Asaka M, Yoshida S.

  Safety of irinotecan and infusional fluorouracil/leucovorin (FOLFIRI) in Japan: a retrospective review of 48 patients with metastatic colorectal cancer.

  Int J of Clin Oncol,13:144-149,2008

• Katagiri A, Fu KI, Sano Y, Ikematsu H, Horimatsu T, Kaneko K, Muto M, Yoshida S.

  Narrow band imaging with magnifying colonoscopy as a diagnostic tool for predicting the histology of early colorectal neoplasia.

  Alim Pharm & Therap 27(12):1269-74,2008

• Sangai T, Fujimoto H, Miyamoto S, Maeda H, Nakamura M, Ishii G, Nagai K, Nagashima T, Miyazaki M, Ochiai A.

  Roles of osteoclasts and bone-derived IGFs in the survival and growth of human breast cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice.

  Clin Exp Metastasis. 2008;25(4):401-10.

• Yamada A, Sasaki H, Aoyagi K, Sano M, Fujii S, Daiko H, Nishimura M, Yoshida T, Chiba T, Ochiai A.

  Expression of cytokeratin 7 predicts survival in stage I/IIA/IIB squamous cell carcinoma of the esophagus.

  Oncol Rep. 2008;20(5):1021-7.

• Matsubara J, Nishina T, Yamada Y, Moriwaki T, Shimoda T, Kajiwara T, Nakajima TE, Kato K, Hamaguchi T, Shimada Y, Okayama Y, Oka T, Shirao K:

  Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer.

  Br J Cancer 2008; 98: 832-839.

• Matsubara J, Okusaka T, Morizane C, Ikeda M, Ueno H:

  Ultrasound-guided percutaneous pancreatic tumor biopsy in pancreatic cancer: a comparison with metastatic liver tumor biopsy, including sensitivity, specificity, and complications.

  J Gastroenterol 2008; 43: 225-232.

• Matsubara J, Yamada Y, Hirashima Y, Takahari D, Okita NT, Kato K, Hamaguchi T, Shirao K, Shimada Y, Shimoda T:

  Impact of insulin-like growth factor type 1 receptor (IGF-1R), epidermal growth factor receptor (EGFR), and HER2 expressions on outcomes of patients with gastric cancer.

  Clin Cancer Res 2008; 14: 3022-3029.

• Matsubara J, Yamada Y, Nakajima TE, Kato K, Hamaguchi T, Shirao K, Shimada Y, Shimoda T:

  Clinical significance of insulin-like growth factor type 1 receptor and epidermal growth factor receptor in patients with advanced gastric cancer.

  Oncology 2008; 74: 76-83.

• Matsubara J, Shimada Y, Takashima A, Takahari D, Hirashima Y, Okita NT, Nakajima TE, Kato K, Hamaguchi T, Yamada Y, Shirao K:

  A phase I study of bolus 5-fluorouracil and leucovorin combined with weekly paclitaxel (FLTAX) as first-line therapy for advanced gastric cancer.

  Jpn J Clin Oncol 2008; 38: 540-546.

• Matsumoto S, Nishimura T, Kanai M, Mori Y, Nagayama S, Kawamura J, Nomura A, Miyamoto S, Kitano T, Ishiguro H, Yanagihara K, Teramukai S, Sakai Y, Chiba T, Fukushima M.

  Safety and efficacy of modified FOLFOX6 for treatment of metastatic or locally advanced colorectal cancer. A single-institution outcome study.

  Chemotherapy 2008;54:395-403.

• Yamada A, Sasaki H, Aoyagi K, Sano M, Fujii S, Daiko H, Nishimura M, Yoshida T, Chiba T, Ochiai A.

  Expression of cytokeratin 7 predicts survival in stage I/IIA/IIB squamous cell carcinoma of the esophagus.

  Oncol Rep. 2008;20(5):1021-7.

2007年

• Muto M, Ochiai A, Yoshida S.

  Detection of superficial cancer in the oropharyngeal and hypopharyngeal mucosal sites and the value of NBI at qualitative diagnosis. In “Advanced Digestive Endoscopy: comprehensive Atlas of High Resolution Endoscopy and Narrowband lmaging”,P35-48, Edited by Jonathan cohen.

  Blackwell publishing 2007

• Minashi K. Muto M. Ohtsu A.

  Non-surgical treatment of superficial esophageal squamous cell carcinoma.

  Esophagus. 4,159-164, 2007

• Takeuchi S, Ohtsu A, Doi T, Kojima T, Minashi K, Mera K, Yano T, Tahara M, Muto M, Nihei K.

  A retrospective study of definitive chemoradiotherapy for elderly patients with esophageal cancer.

  Am J Clin Oncol. ;30(6):607-11, 2007

• Minegishi Y, Tsukino H, Muto M, Goto K, Gemma A, Tsugane S, Kudoh S, Nishiwaki Y, Esumi H.

  Susceptibility to lung cancer and genetic　polymorphisms in the alcohol metabolite-related　enzymes alcohol dehydrogenase 3, aldehyde　dehydrogenase 2, and cytochrome p450 2E1 in the Japanese population.

  Cancer 110:353-362, 2007

• Fuse N, Doi T, Ohtsu A, Takeuchi S, Kojima T, Taku K, Tahara M, Muto M, Asaka M, Yoshida S.

  Feasibility of oxaliplatin and infusional fluorouracil/leucovorin (FOLFOX4) for Japanese patients with unresectable metastatic colorectal cancer.

  Jpn J Clin Oncol.;37(6):434-9, 2007

• Muto M, Fujishiro M, Sato Y, Niwa Y, Kaise M, Kato M, Takubo K.

  Multicenter study design of the ex vivo evaluation of endocytoscopy in esophageal squamous cell carcinoma.

  Dig Endosc 19:S153-5, 2007

• Maekawa K, Saeki M, Saito Y, Ozawa S, Kurose K, Kawamoto M, Kamatani N, Kato K, Hamaguchi T, Yamada Y, Shirao K, Shimada Y, Muto M, Doi T, Ohtsu A, Yoshida T, Matsumura Y, Saijo N, Sawada J.

  Genetic variation and haplotype structures of the DVS gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences.

  J Hum Genetics 52(10):804-819, 2007

• Katada C, Muto M, Momma K, Arima M, Tajiri H, Kanamaru C, Ooyanagi H, Endo H, Michida T, Hasuike N, Oda I, Fujii T, Saito D.

  Clinical outcome after endoscopic mucosal resection for esophageal squamous cell carcinoma invading the muscularis mucosae-a multicenter retrospective cohort study.

  Endoscopy 39:779-783, 2007

• Fujishiro M, Takubo K, Sato Y, Kaise M, Niwa Y, Kato M, Muto M.

  Potential and present limitation of endocytoscopy in the diagnosis of esophageal squamous-cell carcinoma: A multicenter ex vivo pilot study.

  Gastrointest Endosc 66：551-555，2007

• Asakage T, Yokoyama A, Haneda T, Yamazaki M, Manabu Muto, Yokoyama T, Kato H, Igaki H, Tsujinaka T, Kumagai Y, Yokoyama M, Omori T, and Watanabe H.

  Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.

  Carcinogenesis. 28: 865 – 874.2007

• Oyama T, Isse T, Ogawa M, Muto M, Uchiyama I, Kawamoto T.

  Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice.

  Frontiers in Bioscience 12:1927-1934, January 1, 2007

• Miyamoto S, Nakamura M, Yano K, Ishii G, Hasebe T, Endoh Y, Sangai T, Maeda H, Shi-Chuang Z, Chiba T, Ochiai A.

  Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-II via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix.

  Cancer Sci. 2007;98(5):685-91

• Horimatsu T, Fu KI, Sano Y , Matsuda T, Fujimori T, Yoshida S.

  Acute appendicitis as a rare complication after endoscopic mucosal resection.

  Dig Dis Sci. 2007 Jul;52(7):1741-4.

• Fu KI, Horimatsu T, Sano Y, Katagiri A, Fujimori T.

  Metastasis to the appendix from gastric cancer detected incidentally on colonoscopy.

  Endoscopy. 2007.

• Ito T, Tanaka E, Kadowaki T, Kan T, Higashiyama M, Shiojima S, Tomoda S, Myoumoto A, Akiyama H, Nobumasa H, Matsumoto S, Miyamoto S, Mitsumori M, Sato F, Watanabe G, Itami A, Meltzer SJ, Tsujimoto G, Shimada Y.

  An ultrasensitive new DNA microarray chip provides gene expression profiles for preoperative esophageal cancer biopsies without RNA amplification.

  Oncology 2007;73:366-75.

2006年

• Ohashi S, Yazumi S, Nishio A, Fukui T, Asada M, Chiba T.

  Acute cerebral infarction during combination chemotherapy with s-1 and cisplatin for a young patient with a mucin-producing adenocarcinoma of the stomach.

  Internal Medicine. 2006;45(18):1049-53.

• Ohashi S, Yazumi S, Watanabe N, Matsumoto S, Fukui T, Nishio A, Chiba T.Education and imaging.

  MALT lymphoma of the terminal ileum.

  Journal of Gastroenterology and Hepatology, 2006 Sep;21(9):1495.

• Ohashi S, Nishio A, Nakamura H, Asada M, Tamaki H, Kawasaki K, Fukui T, Yodoi J, Chiba T.

  Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice.

  Antioxidants & Redox Signaling. 2006 Sep-Oct;8(9-10):1835-45.

• Ohashi S, Nishio A, Nakamura H, Kido M, Kiriya K, Asada M, Tamaki H, Fukui T, Kawasaki K, Watanabe N, Yodoi J, Okazaki K, Chiba T.

  Clinical Significance of Serum Thioredoxin-1 Levels in Patients with Acute Pancreatitis.

  Pancreas. 2006 Apr;32(3):264-70.

• Ohashi S, Nishio A, Nakamura H, Kido M, Ueno S, Uza N, Inoue S, Kitamura H, Kiriya K, Asada M, Tamaki H, Matsuura M, Kawasaki K, Fukui T, Watanabe N, Nakase H, Yodoi J, Okazaki K, and Chiba T.

  Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitis.

  Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G772-81.

• Sano Y, Horimatsu T, Fu K I, Katagiri A, Muto M, and Ishikawa H.

  Magnifying observation of microvascualr architecture of colorectal lesions using a Narrow-band-imaging system.

  Digestive Endoscopy, Volume 18, Issue s1, Page S44-S51Jul 2006.

• Fujii M, Sakashita M, Wakamura K, Horimatsu T, Tanaka S, Obata D, Iwamoto K, Okabayashi Y.

  Multiple gastric ulcers caused by a rice cake as an intragastric foreign body.

  J Gastroenterol. 2006 Mar;41(3):282-3.

• Fujisawa T, Horimatsu T, Sakaguchi K, Onishi Y, Takeda A, Kishi M, Maeda M,and Nishigami T.

  Duodenal adenoma of gastric foveolar phenotype in the second portion of the duodenum.

  Digestive Endoscopy, Volume 18, Issue 1, Page 62-66, Jan 2006.

• Goya M, Ishii G, Miyamoto S, Hasebe T, Nagai K, Yonou H, Hatano T, Ogawa Y, Ochiai A.

  Prostate-specific antigen induces apoptosis of osteoclast precursors: potential role in osteoblastic bone metastases of prostate cancer.

  Prostate 2006;66:1573-84.

• Fukui T, Sakurai T, Miyamoto S, Ueno S, Kido M, Kiriya K, Inoue S, Ohashi S, Nishio A, Chiba T.

  Gastrointestinal: Epidermal metaplasia of the esophagus.

  J Gastroenterol Hepatol 2006;21:1627.

2005年

• Araki K, Sangai T, Miyamoto S, Maeda H, Shi-Chuang Z, Nakamura M, Ishii G, Hasebe T,　Kusaka H, Akiyama T, Tokuda Y, Nagai K, Minami H, Ochiai A.

  Inhibition of bone-derived insulin-like growth factor of human multiple myeloma in the human　adult bone explanted in NOD/SCID mouse.

  Int J Cancer 2005;118:2602-8

• Nakamura M, Miyamoto S, Maeda H, Ishii G, Hasebe T, Chiba T, Asaka M, Ochiai A.

  Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability.

  Biochem Biophys Res Commun 2005;333:1011-16

• Muto M, Miyamoto S, Hosokawa A, Doi T, Ohtsu A, Yoshida S, Endo Y, Hosokawa K, Saito D, Shim CS, Gossner L.

  Endoscopic mucosal resection in the stomach using the insulated-tip needle-knife.

  Endoscopy 2005;37:178-82

• Miyamoto S, Nakamura M, Shitara K, Nakamura K, Ohki Y, Ishii G, Goya M, Kodama K, Sangai T, Maeda H, Shi-Chuang Z, Chiba T, Ochiai A.

  Blockade of paracrine supply of insulin-like growth factors using neutralizing antibodies suppresses the liver metastasis of human colorectal cancers.

  Clin Cancer Res 2005;11:3494-502

• Sangai T, Ishii G, Kodama K, Miyamoto S, Aoyagi Y, Ito T, Magae J, Sasaki H, Nagashima T, Miyazaki M, Ochiai A.

  Effect of differences in cancer cells and tumor growth sites on recruiting bone marrow-derived endothelial cells and myofibroblasts in cancer-induced stroma.

  Int J Cancer 2005;115:885-92.

• Kodama K, Ishii G, Miyamoto S, Goya M, Zhang SC, Sangai T, Yoshikawa T, Hasebe T, Hitomi Y, Izumi K, Ochiai A.

  Laminin 5 expression protects against anoikis at aerogenous spread and lepidic growth of human lung adenocarcinoma.

  Int J Cancer 2005;116:876-84.

2004年

• Nakamura M, Miyamoto S, Maeda H, Zhang S, Sangai T, Ishii G, Hasebe T, Endoh Y, Saitoh N, Asaka M, Ochiai A.

  Low levels of insulin-like growth factor type 1 receptor expression can predict the hepatic metastasis in Dukes’ C human colorectal cancers.

  Clin Cancer Res 2004;10:8434-41

• Goya M, Miyamoto S, Ohki Y, Nakamura K, Shitara K, Maeda H, Sangai T, Kodama K, Endoh Y, Ishii G, Hasebe T, Nagai K, Yonou H, Hatano T, Ogawa Y, Ochiai A.

  Growth inhibition of human prostate cancer cells in human adult bone implanted into non-obese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors.

  Cancer Res 2004;64:6252-8

• Miyamoto S, Endoh Y, Hasebe T, Ishii G, Kodama K, Goya M, Ono M, Saitoh N, Chiba T, Ochiai A.

  Nuclear ?-catenin accumulation as a prognostic factor in Dukes’ D human colorectal cancers.

  Oncol Rep 2004;12:245-51

• Miyamoto S, Yano K, Sugimoto S, Ishii G, Hasebe T, Endoh Y, Kodama K, Goya M, Chiba T, Ochiai A.

  Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3.

  Cancer Res 2004;64:665-71

• Lim SC, Zhang S, Ishii G, Endoh Y, Kodama K, Miyamoto S, Hayashi R, Ebihara S, Cho JS, Ochiai A.

  Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue.

  Clin Cancer Res 2004;10:166-72.

• Kusakai G, Suzuki A, Ogura T, Miyamoto S, Ochiai A, Kaminishi M, Esumi H.

  ARK5 expression in colorectal cancer and its implications for tumor progression.

  Am J Pathol 004;164:987-95.

• Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Miyamoto S, Ogura T, Ochiai A, Esumi H.

  Regulation of caspase-6 and FLIP by the AMPK family member ARK5.

  Oncogene 2004;23:7067-75.